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Case Reports
. 2014 Dec 5;2(11):e252.
doi: 10.1097/GOX.0000000000000215. eCollection 2014 Nov.

Lymphoepithelioma-like Carcinoma of the Skin: A Case with Perineural Invasion

Cecilie B Lassen  1 , Jørgen Lock-Andersen  1
Affiliations
Case Reports

Lymphoepithelioma-like Carcinoma of the Skin: A Case with Perineural Invasion

Cecilie B Lassen et al. Plast Reconstr Surg Glob Open. .

Abstract

Lymphoepithelioma-like carcinoma of the skin is a rare, low malignant cutaneous neoplasm. We report a case of an elderly woman with lymphoepithelioma-like carcinoma of the skin in the forehead. The tumor was mistaken first as actinic keratosis and later as metastatic squamous cell carcinoma. A histological reassessment showed lymphoepithelioma-like carcinoma of the skin with perineural invasion, which is rare and considered more aggressive. The patient therefore received adjuvant radiotherapy after the recommended wide excision. Lymphoepithelioma-like carcinoma of the skin is a variant of squamous cell carcinoma, and histologically, it resembles the more aggressive lymphoepithelioma of the nasopharynx. The later is Epstein-Barr positive, whereas lymphoepithelioma-like carcinoma normally is not. Lymphoepithelioma-like carcinoma is an important diagnosis to know and the disease is discussed.

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Conflict of interest statement

Disclosure: The authors have no financial interest to declare in relation to the content of this article. The Article Processing Charge was paid for by the authors.

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