Isolation and characterization of a novel arenavirus harbored by Rodents and Shrews in Zhejiang province, China

doi:10.1016/j.virol.2014.11.026

. 2015 Feb:476:37-42.

doi: 10.1016/j.virol.2014.11.026. Epub 2014 Dec 12.

Isolation and characterization of a novel arenavirus harbored by Rodents and Shrews in Zhejiang province, China

Kun Li¹, Xian-Dan Lin², Wen Wang¹, Mang Shi³, Wen-Ping Guo¹, Xiao-He Zhang², Jian-Guang Xing⁴, Jin-Rong He¹, Ke Wang⁵, Ming-Hui Li¹, Jian-Hai Cao⁶, Mu-Liu Jiang⁷, Edward C Holmes⁸, Yong-Zhen Zhang⁹

Affiliations

¹ State Key Laboratory for Infectious Disease Prevention and Control, Department of Zoonoses, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Changping, Beijing, China; Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Hangzhou, China.
² Wenzhou Center for Disease Control and Prevention, Wenzhou, Zhejiang Province, China.
³ State Key Laboratory for Infectious Disease Prevention and Control, Department of Zoonoses, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Changping, Beijing, China; Wencheng Center for Disease Control and Prevention, Wenzhou, Zhejiang Province, China.
⁴ Wencheng Center for Disease Control and Prevention, Wenzhou, Zhejiang Province, China.
⁵ Lucheng Center for Disease Control and Prevention, Wenzhou, Zhejiang Province, China.
⁶ Longwan Center for Disease Control and Prevention, Wenzhou, Zhejiang Province, China.
⁷ Ruian Center for Disease Control and Prevention, Ruian, Zhejiang Province, China.
⁸ State Key Laboratory for Infectious Disease Prevention and Control, Department of Zoonoses, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Changping, Beijing, China; Marie Bashir Institute for Infectious Diseases and Biosecurity, Charles Perkins Centre, School of Biological Sciences and Sydney Medical School, The University of Sydney, Sydney, Australia.
⁹ State Key Laboratory for Infectious Disease Prevention and Control, Department of Zoonoses, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Changping, Beijing, China; Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Hangzhou, China. Electronic address: zhangyongzhen@icdc.cn.

PMID: 25506671
DOI: 10.1016/j.virol.2014.11.026

Free article

Isolation and characterization of a novel arenavirus harbored by Rodents and Shrews in Zhejiang province, China

Kun Li et al. Virology. 2015 Feb.

Free article

. 2015 Feb:476:37-42.

doi: 10.1016/j.virol.2014.11.026. Epub 2014 Dec 12.

Authors

Affiliations

¹ State Key Laboratory for Infectious Disease Prevention and Control, Department of Zoonoses, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Changping, Beijing, China; Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Hangzhou, China.
² Wenzhou Center for Disease Control and Prevention, Wenzhou, Zhejiang Province, China.
³ State Key Laboratory for Infectious Disease Prevention and Control, Department of Zoonoses, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Changping, Beijing, China; Wencheng Center for Disease Control and Prevention, Wenzhou, Zhejiang Province, China.
⁴ Wencheng Center for Disease Control and Prevention, Wenzhou, Zhejiang Province, China.
⁵ Lucheng Center for Disease Control and Prevention, Wenzhou, Zhejiang Province, China.
⁶ Longwan Center for Disease Control and Prevention, Wenzhou, Zhejiang Province, China.
⁷ Ruian Center for Disease Control and Prevention, Ruian, Zhejiang Province, China.
⁸ State Key Laboratory for Infectious Disease Prevention and Control, Department of Zoonoses, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Changping, Beijing, China; Marie Bashir Institute for Infectious Diseases and Biosecurity, Charles Perkins Centre, School of Biological Sciences and Sydney Medical School, The University of Sydney, Sydney, Australia.
⁹ State Key Laboratory for Infectious Disease Prevention and Control, Department of Zoonoses, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Changping, Beijing, China; Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Hangzhou, China. Electronic address: zhangyongzhen@icdc.cn.

PMID: 25506671
DOI: 10.1016/j.virol.2014.11.026

Abstract

To determine the biodiversity of arenaviruses in China, we captured and screened rodents and shrews in Wenzhou city, Zhejiang province, a locality where hemorrhagic fever diseases are endemic in humans. Accordingly, arenaviruses were detected in 42 of 351 rodents from eight species, and in 12 of 272 Asian house shrews (Suncus murinus), by RT-PCR targeting the L segment. From these, a single arenavirus was successfully isolated in cell culture. The virion particles exhibited a typical arenavirus morphology under transmission electron microscopy. Comparison of the S and L segment sequences revealed high levels of nucleotide (>32.2% and >39.6%) and amino acid (>28.8% and >43.8%) sequence differences from known arenaviruses, suggesting that it represents a novel arenavirus, which we designated Wenzhou virus (WENV). Phylogenetic analysis revealed that all WENV strains harbored by both rodents and Asian house shrews formed a distinct lineage most closely related to Old World arenaviruses.

Keywords: Arenavirus; Cross-species transmission; Emergence; Rodents; Shrews; Spill-over.

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Isolation and characterization of a novel arenavirus harbored by Rodents and Shrews in Zhejiang province, China

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Isolation and characterization of a novel arenavirus harbored by Rodents and Shrews in Zhejiang province, China

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