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. 2014 Dec;32(4):292-8.
doi: 10.1016/j.rpped.2014.06.001.

[Clinical, laboratorial and radiographic predictors of Bordetella pertussis infection]

[Article in Portuguese]
Camila Vieira Bellettini  1 , Andressa Welter de Oliveira  1 , Cintia Tusset  1 , Ludmila Fiorenzano Baethgen  1 , Sérgio Luís Amantéa  2 , Fabrizio Motta  2 , Aline Gasparotto  2 , Huander Felipe Andreolla  2 , Alessandro C Pasqualotto  3
Affiliations

[Clinical, laboratorial and radiographic predictors of Bordetella pertussis infection]

[Article in Portuguese]
Camila Vieira Bellettini et al. Rev Paul Pediatr. 2014 Dec.

Abstract

OBJECTIVE:: To identify clinical, laboratorial and radiographic predictors for Bordetella pertussis infection.

METHODS:: This was a retrospective study, which analyzed medical records of all patients submitted to a molecular dignosis (qPCR) for B. pertussis from September 2011 to January 2013. Clinical and laboratorial data were reviewed, including information about age, sex, signs/symptoms, length of hospitalization, blood cell counts, imaging findings, coinfection with other respiratory pathogens and clinical outcome.

RESULTS:: 222 cases were revised. Of these, 72.5% had proven pertussis, and 60.9% were under 1 year old. In patients aging up to six months, independent predictors for B. pertussis infection were (OR 8.0, CI 95% 1.8-36.3; p=0.007) and lymphocyte count >104/µL (OR 10.0, CI 95% 1.8-54.5; p=0.008). No independent predictors of B. pertussis infection could be determined for patients older than six months. Co-infection was found in 21.4% of patients, of which 72.7% were up to six months of age. Adenovirus was the most common agent (40.9%). In these patients, we were not able to identify any clinical features to detect patients presenting with a respiratory co-infection, even though longer hospital stay was observed in patients with co-infections (12 vs. 6 days; p=0.009).

CONCLUSIONS:: Cyanosis and lymphocytosis are independent predictors for pertussis in children up to 6 months old.

Keywords: Bordetella pertussis; Coinfection; Coinfecção; Coqueluche; Infection; Infecção; Whooping cough.

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Conflict of interest statement

Conflicts of interest The authors declare no conflitcts of interest.

Figures

Figure 1
Figure 1. Frequency of codetection of other respiratory pathogens in patients with Bordetella pertussis infection
Figura 1
Figura 1. Frequência de codetecção de outros patógenos respiratórios em pacientes com infecção por Bordetella pertussis.
See this image and copyright information in PMC

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