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Comment
. 2015 Mar;11(3):138-9.
doi: 10.1038/nrendo.2014.220. Epub 2014 Dec 16.

Bone: Will breast cancer chemoprevention stand on 'solid bone'?

Larry J Suva  1 , Issam Makhoul  1
Affiliations
Comment

Bone: Will breast cancer chemoprevention stand on 'solid bone'?

Larry J Suva et al. Nat Rev Endocrinol. 2015 Mar.

Abstract

Aromatase inhibitors are the most effective agents for preventing breast cancer; however, their use is associated with bone loss and an increased risk of fractures. Sestak and colleagues show that administration of an oral bisphosphonate prevents aromatase-inhibitor-induced bone loss in postmenopausal women with osteopenia or osteoporosis who are at high risk of breast cancer.

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Conflict of interest statement

Competing interests

The authors declare no competing interests.

Comment on

References

    1. Cuzick J, et al. Anastrozole for prevention of breast cancer in high-risk postmenopausal women (IBIS-II): an international, double-blind, randomised placebo-controlled trial. Lancet. 2014;383:1041–1048. - PubMed
    1. Goss PE, et al. Exemestane for breast-cancer prevention in postmenopausal women. N Engl J Med. 2011;364:2381–2391. - PubMed
    1. Sestak I, et al. Changes in bone mineral density at 3 years in postmenopausal women receiving anastrozole and risedronate in the IBIS-II bone substudy: an international, double-blind, randomised, placebo-controlled trial. Lancet Oncol. 2014;15:1460–1468. - PubMed
    1. Ten Have TR, et al. Intent-to-treat vs. non-intent-to-treat analyses under treatment non-adherence in mental health randomized trials. Psychiatr Ann. 2008;38:772–783. - PMC - PubMed
    1. Van Poznak CH, et al. American Society of Clinical Oncology executive summary of the clinical practice guideline update on the role of bone-modifying agents in metastatic breast cancer. J Clin Oncol. 2011;29:1221–1227. - PubMed

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