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. 2014 Dec 15;592(24):5341-3.
doi: 10.1113/jphysiol.2014.273615.

CrossTalk proposal: The dominant mechanism causing disuse muscle atrophy is decreased protein synthesis

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CrossTalk proposal: The dominant mechanism causing disuse muscle atrophy is decreased protein synthesis

Stuart M Phillips et al. J Physiol. .
No abstract available

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References

    1. Adams GR, Caiozzo VJ, Baldwin KM. Skeletal muscle unweighting: spaceflight and ground-based models. J Appl Physiol (1985) 2003;95:2185–2201. - PubMed
    1. Bohe J, Low JF, Wolfe RR, Rennie MJ. Latency and duration of stimulation of human muscle protein synthesis during continuous infusion of amino acids. J Physiol. 2001;532:575–579. - PMC - PubMed
    1. Breen L, Stokes KA, Churchward-Venne TA, Moore DR, Baker SK, Smith K, Atherton PJ, Phillips SM. Two weeks of reduced activity decreases leg lean mass and induces ‘anabolic resistance’ of myofibrillar protein synthesis in healthy elderly. J Clin Endocrinol Metab. 2013;98:2604–2612. - PubMed
    1. de Boer MD, Selby A, Atherton P, Smith K, Seynnes OR, Maganaris CN, Maffulli N, Movin T, Narici MV, Rennie MJ. The temporal responses of protein synthesis, gene expression and cell signalling in human quadriceps muscle and patellar tendon to disuse. J Physiol. 2007;585:241–251. - PMC - PubMed
    1. Drummond MJ, Dickinson JM, Fry CS, Walker DK, Gundermann DM, Reidy PT, Timmerman KL, Markofski MM, Paddon-Jones D, Rasmussen BB, Volpi E. Bed rest impairs skeletal muscle amino acid transporter expression, mTORC1 signaling, and protein synthesis in response to essential amino acids in older adults. Am J Physiol Endocrinol Metab. 2012;302:E1113–E1122. - PMC - PubMed

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