The road to clinical use of high-intensity focused ultrasound for liver cancer: technical and clinical consensus

Jean-Francois Aubry¹, Kim Butts Pauly², Chrit Moonen³, Gail Ter Haar⁴, Mario Ries³, Rares Salomir⁵, Sham Sokka⁶, Kevin Michael Sekins⁷, Yerucham Shapira⁸, Fangwei Ye⁹, Heather Huff-Simonin¹⁰, Matt Eames¹⁰, Arik Hananel¹⁰, Neal Kassell¹⁰, Alessandro Napoli¹¹, Joo Ha Hwang¹², Feng Wu¹³, Lian Zhang¹⁴, Andreas Melzer¹⁵, Young-Sun Kim¹⁶, Wladyslaw M Gedroyc¹⁷

Affiliations

¹ Institut Langevin, ESPCI ParisTech, CNRS UMR 7587, INSERM U979, Université Denis Diderot, Paris VII, Paris, France ; Department of Radiation Oncology, University of Virginia, Charlottesville, VA, USA.
² Radiological Sciences Laboratory, Stanford University School of Medicine, Palo Alto, CA, USA.
³ Imaging Division, University Medical Center Utrecht, Amsterdam, The Netherlands.
⁴ Division of Radiotherapy and Imaging, The Institute of Cancer Research, Royal Marsden Hospital, Sutton, Surrey, UK.
⁵ Faculty of Medicine, University of Geneva, Geneva, Switzerland.
⁶ Philips Healthcare, Boston, MA, USA.
⁷ Ultrasound Innovations Applications, Siemens Healthcare, Issaquah, WA, USA.
⁸ InSightec Ltd, 5 Nahum Heth Street, Haifa, Israel.
⁹ Chongqing Haifu Medical Technology Co., Ltd, Chongqing, China.
¹⁰ Focused Ultrasound Foundation, Charlottesville, VA, USA.
¹¹ University of Rome, La Sapienza, Rome, Italy.
¹² Digestive Disease Center, University of Washington, Seattle, WA, USA.
¹³ Institute of Ultrasonic Engineering in Medicine, Chongqing Medical University, Chongqing, China.
¹⁴ Clinical Center for Tumor Therapy, Second Affiliated Hospital of Chongqing University of Medical Sciences, Chongqing, China.
¹⁵ Institute for Medical Science and Technology, University of Dundee, Dundee, Scotland, UK.
¹⁶ Department of Radiology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea.
¹⁷ Department of Medicine, Imperial College, South Kensington Campus, Exhibition Rd, London SW7 2AZ, UK ; Saint Mary's Hospital, Praed St, W2 1NY, London, UK.

PMID: 25512859
PMCID: PMC4265946
DOI: 10.1186/2050-5736-1-13

Review

The road to clinical use of high-intensity focused ultrasound for liver cancer: technical and clinical consensus

Jean-Francois Aubry et al. J Ther Ultrasound. 2013.

. 2013 Aug 1:1:13.

doi: 10.1186/2050-5736-1-13. eCollection 2013.

Authors

Affiliations

¹ Institut Langevin, ESPCI ParisTech, CNRS UMR 7587, INSERM U979, Université Denis Diderot, Paris VII, Paris, France ; Department of Radiation Oncology, University of Virginia, Charlottesville, VA, USA.
² Radiological Sciences Laboratory, Stanford University School of Medicine, Palo Alto, CA, USA.
³ Imaging Division, University Medical Center Utrecht, Amsterdam, The Netherlands.
⁴ Division of Radiotherapy and Imaging, The Institute of Cancer Research, Royal Marsden Hospital, Sutton, Surrey, UK.
⁵ Faculty of Medicine, University of Geneva, Geneva, Switzerland.
⁶ Philips Healthcare, Boston, MA, USA.
⁷ Ultrasound Innovations Applications, Siemens Healthcare, Issaquah, WA, USA.
⁸ InSightec Ltd, 5 Nahum Heth Street, Haifa, Israel.
⁹ Chongqing Haifu Medical Technology Co., Ltd, Chongqing, China.
¹⁰ Focused Ultrasound Foundation, Charlottesville, VA, USA.
¹¹ University of Rome, La Sapienza, Rome, Italy.
¹² Digestive Disease Center, University of Washington, Seattle, WA, USA.
¹³ Institute of Ultrasonic Engineering in Medicine, Chongqing Medical University, Chongqing, China.
¹⁴ Clinical Center for Tumor Therapy, Second Affiliated Hospital of Chongqing University of Medical Sciences, Chongqing, China.
¹⁵ Institute for Medical Science and Technology, University of Dundee, Dundee, Scotland, UK.
¹⁶ Department of Radiology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea.
¹⁷ Department of Medicine, Imperial College, South Kensington Campus, Exhibition Rd, London SW7 2AZ, UK ; Saint Mary's Hospital, Praed St, W2 1NY, London, UK.

PMID: 25512859
PMCID: PMC4265946
DOI: 10.1186/2050-5736-1-13

Abstract

Clinical use of high-intensity focused ultrasound (HIFU) under ultrasound or MR guidance as a non-invasive method for treating tumors is rapidly increasing. Tens of thousands of patients have been treated for uterine fibroid, benign prostate hyperplasia, bone metastases, or prostate cancer. Despite the methods' clinical potential, the liver is a particularly challenging organ for HIFU treatment due to the combined effect of respiratory-induced liver motion, partial blocking by the rib cage, and high perfusion/flow. Several technical and clinical solutions have been developed by various groups during the past 15 years to compensate for these problems. A review of current unmet clinical needs is given here, as well as a consensus from a panel of experts about technical and clinical requirements for upcoming pilot and pivotal studies in order to accelerate the development and adoption of focused ultrasound for the treatment of primary and secondary liver cancer.

Keywords: Focused ultrasound; High-intensity ultrasound; Liver cancer; Non-invasive surgery; Ultrasound.

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References

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The road to clinical use of high-intensity focused ultrasound for liver cancer: technical and clinical consensus

Affiliations

The road to clinical use of high-intensity focused ultrasound for liver cancer: technical and clinical consensus

Authors

Affiliations

Abstract

References

Publication types

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Full Text Sources

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Miscellaneous