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. 1989 Sep 29;163(3):1450-5.
doi: 10.1016/0006-291x(89)91141-8.

Deficiencies in complex I subunits of the respiratory chain in Parkinson's disease

Y Mizuno  1 , S Ohta, M Tanaka, S Takamiya, K Suzuki, T Sato, H Oya, T Ozawa, Y Kagawa
Affiliations

Deficiencies in complex I subunits of the respiratory chain in Parkinson's disease

Y Mizuno et al. Biochem Biophys Res Commun. .

Abstract

Immunoblotting studies on mitochondria prepared from the striata of patients who died of Parkinson's disease were performed using specific antisera against Complexes I, III and IV. In 4 out of 5 patients with Parkinson's disease, the 30-, 25- and 24-kDa subunits of Complex I were moderately to markedly decreased. No clear difference was noted in immunoblotting studies on subunits of Complexes III and IV between the control and Parkinson's disease. Deficiencies in Complex I subunits seem to be one of the most important clues to elucidate pathogenesis of Parkinson's disease.

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