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Comment
. 2014 Nov 6;56(3):345-346.
doi: 10.1016/j.molcel.2014.10.023. Epub 2014 Nov 6.

Ribosomes left in the dust: diverse strategies for Peptide-mediated translation stalling

Benjamin H Hudson  1 , Hani S Zaher  2
Affiliations
Comment

Ribosomes left in the dust: diverse strategies for Peptide-mediated translation stalling

Benjamin H Hudson et al. Mol Cell. .

Abstract

In two recent papers, Arenz et al. (2014a) and Bischoff et al. (2014) provide structural insights into drug-induced, peptide-mediated stalling of the ribosome.

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Figures

Figure 1.
Figure 1.. Diverse Strategies for Peptide-Mediated Translation Stalling
Left: schematic of the interactions between the indicated nascent peptide, ligands, and the exit tunnel of the ribosome. Right: resulting conformational changes to the peptidyl-transferase center from these interactions.
See this image and copyright information in PMC

Comment on

References

    1. Arenz S, Meydan S, Starosta AL, Berninghausen O, Beckmann R, Vázquez-Laslop N, and Wilson DN (2014a). Mol. Cell 56, this issue, 446–452. - PMC - PubMed
    1. Aren S., Ram H., Gupt P., Berninghause O., Beckman R, Vázquez-Laslop N, Mankin AS, and Wilson DN (2014b). Nat. Commun 5, 3501. - PMC - PubMed
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    1. Bischoff L, Berninghausen O, and Beckmann R (2014). Cell Rep. 9, 469–475. - PubMed
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