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Review
. 2015 Feb;27(1):110-5.
doi: 10.1097/MOP.0000000000000184.

Importance of viruses in acute otitis media

Johanna Nokso-Koivisto  1 , Tal Marom, Tasnee Chonmaitree
Affiliations
Review

Importance of viruses in acute otitis media

Johanna Nokso-Koivisto et al. Curr Opin Pediatr. 2015 Feb.

Abstract

Purpose of review: Acute otitis media occurs as a complication of viral upper respiratory tract infection. Bacterial otopathogens and respiratory viruses interact and play important roles in acute otitis media development. A better understanding of viral and bacterial interactions may lead to innovative ways to lessen the burden of this common childhood disease.

Recent findings: There has been increasing evidence that acute otitis media occurs during upper respiratory infection, even in the absence of nasopharyngeal bacterial colonization. Among the types of viruses associated with acute otitis media, respiratory syncytial virus continues to be the most commonly detected. It is still unclear whether viral load plays an important role in acute otitis media development, but symptomatic upper respiratory tract infection (as opposed to asymptomatic viral infection) is crucial. Widespread use of bacterial and viral vaccines in young children, including pneumococcal conjugate and influenza vaccines, has led to the reduction in otitis media-related healthcare use between 2001 and 2011. There has been no new vaccine against respiratory viruses other than influenza.

Summary: Progress has been made toward the reduction of the burden of acute otitis media in the last decade. Success in reducing acute otitis media incidence will rely mainly on prevention of nasopharyngeal otopathogen colonization, as well as reduction in the incidence of viral upper respiratory tract infection.

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Conflict of interest statement

No conflicts of interest

Figures

Figure 1
Figure 1
Simplified steps of the pathogenesis of virus-induced acute otitis media
See this image and copyright information in PMC

References

    1. Chonmaitree T, Revai K, Grady JJ, Clos A, Patel JA, Nair S, et al. Viral upper respiratory tract infection and otitis media complication in young children. Clin Infect Dis. 2008;46(6):815–23. - PMC - PubMed
    1. Kalu SU, Ataya RS, McCormick DP, Patel JA, Revai K, Chonmaitree T. Clinical spectrum of acute otitis media complicating upper respiratory tract viral infection. Pediatr Infect Dis J. 2011;30(2):95–9. - PMC - PubMed
    1. Grijalva CG, Nuorti JP, Griffin MR. Antibiotic prescription rates for acute respiratory tract infections in US ambulatory settings. JAMA. 2009;302(7):758–66. - PMC - PubMed
    1. Marom T, Tan A, Wilkinson GS, Pierson KS, Freeman JL, Chonmaitree T. Trends in otitis media-related health care use in the United States, 2001–2011. JAMA Pediatr. 2014;168(1):68–75. This article reports the most recent downward trend in otitis media-related healthcare use, mainly from pneumococcal conjugate vaccines but the trend likely incorporated the effect of influenza vaccination and other factors also. - PMC - PubMed
    1. Lieberthal AS, Carroll AE, Chonmaitree T, Ganiats TG, Hoberman A, Jackson MA, et al. The diagnosis and management of acute otitis media. Pediatrics. 2013;131(3):e964–99. - PubMed

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