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Editorial
. 2015 Apr 1;60(7):1128-30.
doi: 10.1093/cid/ciu1138. Epub 2014 Dec 16.

Editorial commentary: immunodeficiency at start of antiretroviral therapy: the persistent problem of late presentation to care

Affiliations
Editorial

Editorial commentary: immunodeficiency at start of antiretroviral therapy: the persistent problem of late presentation to care

Nathan Ford et al. Clin Infect Dis. .
No abstract available

Keywords: CD4; antiretroviral therapy; ecological bias; immunodeficiency; late presentation.

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Figures

Figure 1.
Figure 1.
Ecological bias: hypothetical example of aggregate and individual level CD4 cell count data at the start of antiretroviral therapy (ART). In 5 of 6 programs, the CD4 cell count at the start of ART increased over calendar time (solid regression lines), yet the regression line fit to the aggregated data indicates that there was no change (broken regression line).

Comment on

References

    1. Meyer-Rath G, Brennan AT, Fox MP, et al. Rates and cost of hospitalization before and after initiation of antiretroviral therapy in urban and rural settings in South Africa. J Acquir Immune Defic Syndr. 2013;62:322–8. - PMC - PubMed
    1. Hogg RS, Yip B, Chan KJ, et al. Rates of disease progression by baseline CD4 cell count and viral load after initiating triple-drug therapy. JAMA. 2001;286:2568–77. - PubMed
    1. May M, Boulle A, Phiri S, et al. Prognosis of patients with HIV-1 infection starting antiretroviral therapy in sub-Saharan Africa: a collaborative analysis of scale-up programmes. Lancet. 2010;376:449–57. - PMC - PubMed
    1. Johnson LF, Mossong J, Dorrington RE, et al. Life expectancies of South African adults starting antiretroviral treatment: collaborative analysis of cohort studies. PLoS Med. 2013;10:e1001418. - PMC - PubMed
    1. Mills EJ, Bakanda C, Birungi J, et al. Life expectancy of persons receiving combination antiretroviral therapy in low-income countries: a cohort analysis from Uganda. Ann Intern Med. 2011;155:209–16. - PubMed