Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Meta-Analysis
. 2014 Dec 14;20(46):17635-47.
doi: 10.3748/wjg.v20.i46.17635.

Helicobacter pylori infection and atopic diseases: is there a relationship? A systematic review and meta-analysis

Elena Lionetti  1 , Salvatore Leonardi  1 , Angela Lanzafame  1 , Maria Teresa Garozzo  1 , Martina Filippelli  1 , Stefania Tomarchio  1 , Viviana Ferrara  1 , Carmelo Salpietro  1 , Alfredo Pulvirenti  1 , Ruggiero Francavilla  1 , Carlo Catassi  1
Affiliations
Meta-Analysis

Helicobacter pylori infection and atopic diseases: is there a relationship? A systematic review and meta-analysis

Elena Lionetti et al. World J Gastroenterol. .

Abstract

Aim: To review and conduct a meta-analysis of the existing literature on the relationship between Helicobacter pylori (H. pylori), atopy and allergic diseases.

Methods: Studies published in English assessing the prevalence of atopy and/or allergic diseases in patients with H. pylori infection and the prevalence of H. pylori infection in patients with atopy and/or allergic diseases were identified through a MEDLINE search (1950-2014). Random-effect model was used for the meta-analysis.

Results: Pooled results of case-control studies showed a significant inverse association of H. pylori infection with atopy/allergic disease or with exclusively atopy, but not with allergic disease, whereas pooled results of cross-sectional studies showed only a significant association between allergic disease and H. pylori infection.

Conclusion: There is some evidence of an inverse association between atopy/allergic diseases and H. pylori infection, although further studied are needed.

Keywords: Allergic diseases; Atopy; Helicobacter pylori; Hygiene hypothesis; Infection.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Meta-analysis of case-control studies. A: Concerning atopy/allergic diseases and Helicobacter pylori (H. pylori) infection; B: Concerning atopy and H. pylori infection; C: concerning allergic diseases and H. pylori infection; D: Concerning allergic diseases and H. pylori infection.
Figure 2
Figure 2
Meta-analysis of cross-sectional studies. A: Concerning atopy/allergic diseases and Helicobacter pylori (H. pylori) infection; B: Concerning atopy and H. pylori infection.
See this image and copyright information in PMC

References

    1. Mallol J, Crane J, von Mutius E, Odhiambo J, Keil U, Stewart A. The International Study of Asthma and Allergies in Childhood (ISAAC) Phase Three: a global synthesis. Allergol Immunopathol (Madr) 2013;41:73–85. - PubMed
    1. Rigoli L, Briuglia S, Caimmi S, Ferraú V, Gallizzi R, Leonardi S, La Rosa M, Salpietro C. Gene-environment interaction in childhood asthma. Int J Immunopathol Pharmacol. 2011;24:41–47. - PubMed
    1. Marshall GD. Internal and external environmental influences in allergic diseases. J Am Osteopath Assoc. 2004;104:S1–S6. - PubMed
    1. Nicolaou N, Siddique N, Custovic A. Allergic disease in urban and rural populations: increasing prevalence with increasing urbanization. Allergy. 2005;60:1357–1360. - PubMed
    1. WHO European Centre for Environment and Health. Effects of air pollution on children’s health and development - a review of the evidence. Copenhagen, WHO Regional Office for Europe, 200. Accessed 6 March, 2007. Available from: http://www.euro.who.int/document/E86575.pdf.