Centriole duplication: when PLK4 meets Ana2/STIL

Minhee Kim¹, Chii Shyang Fong², Meng-Fu Bryan Tsou³

Affiliations

¹ Cell Biology Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA; Weill Cornell Graduate School of Medical Sciences, Cornell University, New York, NY 10065, USA.
² Cell Biology Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.
³ Cell Biology Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA; Weill Cornell Graduate School of Medical Sciences, Cornell University, New York, NY 10065, USA. Electronic address: tsoum@mskcc.org.

PMID: 25517369
DOI: 10.1016/j.cub.2014.09.079

Free article

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Centriole duplication: when PLK4 meets Ana2/STIL

Minhee Kim et al. Curr Biol. 2014.

Free article

. 2014 Nov 3;24(21):R1046-8.

doi: 10.1016/j.cub.2014.09.079. Epub 2014 Nov 3.

Authors

Minhee Kim¹, Chii Shyang Fong², Meng-Fu Bryan Tsou³

Affiliations

¹ Cell Biology Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA; Weill Cornell Graduate School of Medical Sciences, Cornell University, New York, NY 10065, USA.
² Cell Biology Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.
³ Cell Biology Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA; Weill Cornell Graduate School of Medical Sciences, Cornell University, New York, NY 10065, USA. Electronic address: tsoum@mskcc.org.

PMID: 25517369
DOI: 10.1016/j.cub.2014.09.079

Abstract

Polo-like kinase 4 is known to drive centriole duplication, but the relevant substrate remains elusive. A new study shows that PLK4 phosphorylates a key centriolar component, Ana2/STIL, to initiate centriole assembly.

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Plk4 phosphorylates Ana2 to trigger Sas6 recruitment and procentriole formation.
Dzhindzhev NS, Tzolovsky G, Lipinszki Z, Schneider S, Lattao R, Fu J, Debski J, Dadlez M, Glover DM. Dzhindzhev NS, et al. Curr Biol. 2014 Nov 3;24(21):2526-32. doi: 10.1016/j.cub.2014.08.061. Epub 2014 Sep 25. Curr Biol. 2014. PMID: 25264260 Free PMC article.

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Centriole duplication: when PLK4 meets Ana2/STIL

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Centriole duplication: when PLK4 meets Ana2/STIL

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