"Toll"-erance in the skin

Tina L Sumpter¹, Louis D Falo Jr²

Affiliations

¹ Department of Dermatology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.
² Department of Dermatology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA; Department of Bioengineering, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA; Pittsburgh Clinical and Translational Science Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA; The McGowan Institute for Regenerative Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA; The University of Pittsburgh Cancer Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA. Electronic address: lof2@pitt.edu.

PMID: 25517608
DOI: 10.1016/j.immuni.2014.11.003

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"Toll"-erance in the skin

Tina L Sumpter et al. Immunity. 2014.

Free article

. 2014 Nov 20;41(5):677-9.

doi: 10.1016/j.immuni.2014.11.003. Epub 2014 Nov 20.

Authors

Tina L Sumpter¹, Louis D Falo Jr²

Affiliations

¹ Department of Dermatology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.
² Department of Dermatology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA; Department of Bioengineering, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA; Pittsburgh Clinical and Translational Science Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA; The McGowan Institute for Regenerative Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA; The University of Pittsburgh Cancer Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA. Electronic address: lof2@pitt.edu.

PMID: 25517608
DOI: 10.1016/j.immuni.2014.11.003

Abstract

Interactions between potentially pathogenic commensal bacteria and cutaneous immunity are poorly understood. In this issue of Immunity, Skabytska et al. (2014) show that S. aureus-derived TLR2/6 heterodimer ligands can recruit myeloid-derived suppressor cells into the skin, countering rather than promoting inflammation.

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Cutaneous innate immune sensing of Toll-like receptor 2-6 ligands suppresses T cell immunity by inducing myeloid-derived suppressor cells.
Skabytska Y, Wölbing F, Günther C, Köberle M, Kaesler S, Chen KM, Guenova E, Demircioglu D, Kempf WE, Volz T, Rammensee HG, Schaller M, Röcken M, Götz F, Biedermann T. Skabytska Y, et al. Immunity. 2014 Nov 20;41(5):762-75. doi: 10.1016/j.immuni.2014.10.009. Epub 2014 Nov 13. Immunity. 2014. PMID: 25456159

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"Toll"-erance in the skin

Affiliations

"Toll"-erance in the skin

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Abstract

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