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Comment
. 2014 Nov 10;26(5):593-5.
doi: 10.1016/j.ccell.2014.10.013. Epub 2014 Nov 10.

Building through breaking: the development of cancer neochromosomes

Joshua J Waterfall  1 , Paul S Meltzer  2
Affiliations
Comment

Building through breaking: the development of cancer neochromosomes

Joshua J Waterfall et al. Cancer Cell. .

Abstract

In this issue of Cancer Cell, Garsed and colleagues combine chromosome flow sorting and deep sequencing to characterize the structure of oncogene-containing neochromosomes in liposarcoma and provide evidence that they are generated by a combination of multiple dynamic and destructive processes.

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Comment on

  • The architecture and evolution of cancer neochromosomes.
    Garsed DW, Marshall OJ, Corbin VD, Hsu A, Di Stefano L, Schröder J, Li J, Feng ZP, Kim BW, Kowarsky M, Lansdell B, Brookwell R, Myklebost O, Meza-Zepeda L, Holloway AJ, Pedeutour F, Choo KH, Damore MA, Deans AJ, Papenfuss AT, Thomas DM. Garsed DW, et al. Cancer Cell. 2014 Nov 10;26(5):653-67. doi: 10.1016/j.ccell.2014.09.010. Epub 2014 Nov 10. Cancer Cell. 2014. PMID: 25517748