ChIP-ping away at EWS/ETS transcription networks

Christopher T Denny¹

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Affiliation

¹ Division of Hematology/Oncology, Department of Pediatrics, Gwynne Hazen Cherry Memorial Laboratories, University of California, Los Angeles, Los Angeles, CA 90095, USA; Jonsson Comprehensive Cancer Center, University of California, Los Angeles, Los Angeles, CA 90095, USA; Molecular Biology Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA. Electronic address: cdenny@ucla.edu.

PMID: 25517742
DOI: 10.1016/j.ccell.2014.10.016

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ChIP-ping away at EWS/ETS transcription networks

Christopher T Denny. Cancer Cell. 2014.

Free article

. 2014 Nov 10;26(5):595-6.

doi: 10.1016/j.ccell.2014.10.016. Epub 2014 Nov 10.

Author

Christopher T Denny¹

Affiliation

¹ Division of Hematology/Oncology, Department of Pediatrics, Gwynne Hazen Cherry Memorial Laboratories, University of California, Los Angeles, Los Angeles, CA 90095, USA; Jonsson Comprehensive Cancer Center, University of California, Los Angeles, Los Angeles, CA 90095, USA; Molecular Biology Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA. Electronic address: cdenny@ucla.edu.

PMID: 25517742
DOI: 10.1016/j.ccell.2014.10.016

Abstract

In this issue of Cancer Cell, Riggi and colleagues use a genomic approach to define two distinct molecular mechanisms through which the chimeric EWS/FLI1 oncoprotein regulates target genes in Ewing sarcoma, expanding a framework upon which to model the target gene network and test strategies for antagonizing growth of this tumor.

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EWS-FLI1 utilizes divergent chromatin remodeling mechanisms to directly activate or repress enhancer elements in Ewing sarcoma.
Riggi N, Knoechel B, Gillespie SM, Rheinbay E, Boulay G, Suvà ML, Rossetti NE, Boonseng WE, Oksuz O, Cook EB, Formey A, Patel A, Gymrek M, Thapar V, Deshpande V, Ting DT, Hornicek FJ, Nielsen GP, Stamenkovic I, Aryee MJ, Bernstein BE, Rivera MN. Riggi N, et al. Cancer Cell. 2014 Nov 10;26(5):668-681. doi: 10.1016/j.ccell.2014.10.004. Epub 2014 Oct 30. Cancer Cell. 2014. PMID: 25453903 Free PMC article.

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ChIP-ping away at EWS/ETS transcription networks

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ChIP-ping away at EWS/ETS transcription networks

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