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Review
. 2013 Apr-May;197(4-5):877-86; discussion 886.

[Cryopreservation of testicular tissue in children]

[Article in French]
Nathalie Rives, Jean-Pierre Milazzo, Albanne Travers, Brahim Arkoun, Amandine Bironneau, Louis Sibert, Agnès Liard-Zmuda, Aude Marie-Cardine, Pascale Schneider, Jean-Pierre Vannier, Bertrand Macé
  • PMID: 25518156
Review

[Cryopreservation of testicular tissue in children]

[Article in French]
Nathalie Rives et al. Bull Acad Natl Med. 2013 Apr-May.

Abstract

The toxicity of cancer therapies can affect all organs and tissues. Some treatments damage spermatogonial stem cells (SSCs), with a risk of infertility. Storage and reimplantation of frozen testicular tissue is a recent approach tofertilitypreservationfor young boys. However, thawed frozen prepubertal testicular tissue must undergo a maturation process to restore sperm production. This process, currently being studied in animal models, can be achieved by in vivo transplantation of SSCs into seminiferous tubules or by testicular grafting, possibly following in vitro maturation.

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