Genetic Analysis Workshop 18: Methods and strategies for analyzing human sequence and phenotype data in members of extended pedigrees

Heike Bickeböller¹, Julia N Bailey², Joseph Beyene³, Rita M Cantor⁴, Heather J Cordell⁵, Robert C Culverhouse⁶, Corinne D Engelman⁷, David W Fardo⁸, Saurabh Ghosh⁹, Inke R König¹⁰, Justo Lorenzo Bermejo¹¹, Phillip E Melton¹², Stephanie A Santorico¹³, Glen A Satten¹⁴, Lei Sun¹⁵, Nathan L Tintle¹⁶, Andreas Ziegler¹⁷, Jean W MacCluer¹⁸, Laura Almasy¹⁸

Affiliations

¹ Department of Genetic Epidemiology, University Medicine Göttingen, University of Göttingen, Humboldtallee 32, 37073 Göttingen, Germany.
² Department of Epidemiology, Fielding School of Public Health, University of California, Los Angeles, CA 90095, USA.
³ Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON L8S 4K1, Canada.
⁴ David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA.
⁵ Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne NE1 3BZ, UK.
⁶ Department of Medicine and Division of Biostatistics, Washington University School of Medicine, Saint Louis, MO 63110, USA.
⁷ Department of Population Health Sciences, School of Medicine and Public Health, University of Wisconsin, Madison, WI 53726, USA.
⁸ Department of Biostatistics, University of Kentucky, Lexington, KY 40536, USA.
⁹ Indian Statistical Institute, Kolkata 700108, West Bengal, India.
¹⁰ Institut für Medizinische Biometrie und Statistik, Universität zu Lübeck, Universitätsklinikum Schleswig-Holstein, Campus Lübeck, 23562 Lübeck, Germany.
¹¹ Institute of Medical Biometry and Informatics, University of Heidelberg, 69120 Heidelberg, Germany.
¹² Centre for Genetic Origins of Health and Disease, Statistical Genetics, University of Western Australia, Crawley 6009, Australia.
¹³ Department of Mathematical and Statistical Sciences, University of Colorado, Denver, CO 80217, USA.
¹⁴ Centers for Disease Control and Prevention, Atlanta, GA 30333, USA.
¹⁵ Department of Statistical Sciences, University of Toronto, Toronto, ON M5S 3G3, Canada.
¹⁶ Department of Mathematics, Computer Science and Statistics, Dordt College, Sioux Center, IA 51250, USA.
¹⁷ Institut für Medizinische Biometrie und Statistik, Universität zu Lübeck, Universitätsklinikum Schleswig-Holstein, Campus Lübeck, 23562 Lübeck, Germany ; Zentrum für Klinische Studien, Universität zu Lübeck, 23562 Lübeck, Germany.
¹⁸ Department of Genetics, Texas Biomedical Research Institute, San Antonio, TX 78245, USA.

PMID: 25519310
PMCID: PMC4143625
DOI: 10.1186/1753-6561-8-S1-S1

Genetic Analysis Workshop 18: Methods and strategies for analyzing human sequence and phenotype data in members of extended pedigrees

Heike Bickeböller et al. BMC Proc. 2014.

. 2014 Jun 17;8(Suppl 1):S1.

doi: 10.1186/1753-6561-8-S1-S1. eCollection 2014.

Authors

Affiliations

¹ Department of Genetic Epidemiology, University Medicine Göttingen, University of Göttingen, Humboldtallee 32, 37073 Göttingen, Germany.
² Department of Epidemiology, Fielding School of Public Health, University of California, Los Angeles, CA 90095, USA.
³ Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON L8S 4K1, Canada.
⁴ David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA.
⁵ Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne NE1 3BZ, UK.
⁶ Department of Medicine and Division of Biostatistics, Washington University School of Medicine, Saint Louis, MO 63110, USA.
⁷ Department of Population Health Sciences, School of Medicine and Public Health, University of Wisconsin, Madison, WI 53726, USA.
⁸ Department of Biostatistics, University of Kentucky, Lexington, KY 40536, USA.
⁹ Indian Statistical Institute, Kolkata 700108, West Bengal, India.
¹⁰ Institut für Medizinische Biometrie und Statistik, Universität zu Lübeck, Universitätsklinikum Schleswig-Holstein, Campus Lübeck, 23562 Lübeck, Germany.
¹¹ Institute of Medical Biometry and Informatics, University of Heidelberg, 69120 Heidelberg, Germany.
¹² Centre for Genetic Origins of Health and Disease, Statistical Genetics, University of Western Australia, Crawley 6009, Australia.
¹³ Department of Mathematical and Statistical Sciences, University of Colorado, Denver, CO 80217, USA.
¹⁴ Centers for Disease Control and Prevention, Atlanta, GA 30333, USA.
¹⁵ Department of Statistical Sciences, University of Toronto, Toronto, ON M5S 3G3, Canada.
¹⁶ Department of Mathematics, Computer Science and Statistics, Dordt College, Sioux Center, IA 51250, USA.
¹⁷ Institut für Medizinische Biometrie und Statistik, Universität zu Lübeck, Universitätsklinikum Schleswig-Holstein, Campus Lübeck, 23562 Lübeck, Germany ; Zentrum für Klinische Studien, Universität zu Lübeck, 23562 Lübeck, Germany.
¹⁸ Department of Genetics, Texas Biomedical Research Institute, San Antonio, TX 78245, USA.

PMID: 25519310
PMCID: PMC4143625
DOI: 10.1186/1753-6561-8-S1-S1

Abstract

Genetic Analysis Workshop 18 provided a platform for developing and evaluating statistical methods to analyze whole-genome sequence data from a pedigree-based sample. In this article we present an overview of the data sets and the contributions that analyzed these data. The family data, donated by the Type 2 Diabetes Genetic Exploration by Next-Generation Sequencing in Ethnic Samples Consortium, included sequence-level genotypes based on sequencing and imputation, genome-wide association genotypes from prior genotyping arrays, and phenotypes from longitudinal assessments. The contributions from individual research groups were extensively discussed before, during, and after the workshop in theme-based discussion groups before being submitted for publication.

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References

1. Almasy L, Dyer TD, Peralta JM, Jun G, Wood AR, Fuchsberger C, Almeida MA, Kent JW Jr, Fowler S, Blackwell TW. et al.Data for Genetic Analysis Workshop 18: Human whole genome sequence, blood pressure, and simulated phenotypes in extended pedigrees. BMC Proc. 2014;8(suppl 2):S2. - PMC - PubMed

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Genetic Analysis Workshop 18: Methods and strategies for analyzing human sequence and phenotype data in members of extended pedigrees

Affiliations

Genetic Analysis Workshop 18: Methods and strategies for analyzing human sequence and phenotype data in members of extended pedigrees

Authors

Affiliations

Abstract

References

Grants and funding

LinkOut - more resources

Full Text Sources

Other Literature Sources