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. 2014 Dec 17;96 Suppl 1(Suppl 1):7-11.
doi: 10.2106/JBJS.N.00642.

A distributed health data network analysis of survival outcomes: the International Consortium of Orthopaedic Registries perspective

Samprit Banerjee  1 , Guy Cafri  2 , Abby J Isaacs  1 , Stephen Graves  3 , Elizabeth Paxton  2 , Danica Marinac-Dabic  4 , Art Sedrakyan  1
Affiliations

A distributed health data network analysis of survival outcomes: the International Consortium of Orthopaedic Registries perspective

Samprit Banerjee et al. J Bone Joint Surg Am. .

Abstract

The International Consortium for Orthopaedic Registries is a multinational initiative established by the United States Food and Drug Administration to develop a health data network aimed at providing a robust infrastructure to facilitate evidence-based decision-making on performance of medical devices. Through the International Consortium for Orthopaedic Registries, individual data holders have complete control of their data and can choose to participate in studies of their choice. In this article, we present an overview of the data extraction process and the analytic strategy employed to answer several device performance-related questions in total hip arthroplasty and total knee arthroplasty. In the process, we discuss some nuances pertinent to International Consortium for Orthopaedic Registries data that pose certain statistical challenges, and we briefly suggest strategies to be adopted to address them.

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Figures

Fig. 1
Fig. 1
The ICOR distributed analysis process for total hip arthroplasty in which the ICOR Coordinating Center creates analysis programs and distributes them to six registries (A), registries run the programs on-site and submit resulting Nelson-Aalen survival estimates for all possible covariate combinations (B), and the center uses mixed effects models to combine estimates across groups (C). E-R = Emilia-Romagna.
See this image and copyright information in PMC

References

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