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Editorial
. 2015 Jan;35(1):13-5.
doi: 10.1161/ATVBAHA.114.304869.

Regulation of endothelial cell metabolism: just go with the flow

Xinghui Sun  1 , Mark W Feinberg  2
Affiliations
Editorial

Regulation of endothelial cell metabolism: just go with the flow

Xinghui Sun et al. Arterioscler Thromb Vasc Biol. 2015 Jan.
No abstract available

Keywords: KLF2 protein, human; PFKFB3 protein, human; endothelial cells; laminar shear stress; metabolism.

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Figures

Figure
Figure. The regulation of endothelial cellular metabolism by shear stress through Kruppel-like factor 2 (KLF2) and phosphofructokinase-2/fructose-2,6-bisphosphatase-3 (PFKFB3)
Laminar shear stress reduces endothelial cell (EC) glycolysis by repressing the expression of PFKFB3 in a KLF2-dependent manner, an effect that maintains the quiescent metabolic state of ECs and inhibits angiogenesis. Both KLF2 and laminar shear stress are involved in the regulation of mitochondrial respiration. The effect of laminar shear stress on mitochondrial respiration may depend on the induction of KLF2 or additional unknown regulators. KLF2 also confers EC anti-inflammatory, anti-thrombotic, and anti-oxidative properties. In regions of arteries where ECs are exposed to disturbed flow, or in response to biochemical stimuli such as cytokines, high glucose, and oxidative stress, KLF2 expression is reduced, which contributes to EC activation. Loss of the repressive function of KLF2 on PFKFB3 may induce PFKFB3 expression and increase glycolysis, an effect that may switch quiescent ECs to metabolically active ECs and induce angiogenesis.
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Comment on

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