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. 2014 Dec 3:2:109.
doi: 10.3389/fchem.2014.00109. eCollection 2014.

The application of magnetic nanoparticles for the treatment of brain tumors

Keon Mahmoudi  1 , Costas G Hadjipanayis  2
Affiliations

The application of magnetic nanoparticles for the treatment of brain tumors

Keon Mahmoudi et al. Front Chem. .
No abstract available

Keywords: glioblastoma; hyperthermia; imaging; magnetic nanoparticles; nanoparticles; nanotheranostics.

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Figures

Figure 1
Figure 1
Local hyperthermia treatment of a patient with a malignant brain tumor after implantation of MNPs. (A) The patient undergoes an alternating magnetic field (AMF) session (shown in yellow) for generation of local hyperthermia in the region of the tumor. (B) Oscillation of the MNPs (shown in yellow) within and adjacent to the tumor cells provides the therapeutic hyperthermia (thermotherapy) effect. (C) Local implantation of the MNPs within and adjacent to the brain tumor provides a targeted therapeutic effect. (D) Brain tumor cells shown infiltrating normal brain may be more susceptible to the effects of local hyperthermia by greater MNP intracellular uptake and sensitivity to temperature changes.
See this image and copyright information in PMC

References

    1. Adamson C., Kanu O. O., Mehta A. I., Di C., Lin N., Mattox A. K., et al. . (2009). Glioblastoma multiforme: a review of where we have been and where we are going. Expert Opin. Investig. Drugs 18, 1061–1083. 10.1517/13543780903052764 - DOI - PubMed
    1. Batchelor T. T., Sorensen A. G., Di Tomaso E., Zhang W. T., Duda D. G., Cohen K. S., et al. . (2007). AZD2171, a pan-VEGF receptor tyrosine kinase inhibitor, normalizes tumor vasculature and alleviates edema in glioblastoma patients. Cancer Cell 11, 83–95. 10.1016/j.ccr.2006.11.021 - DOI - PMC - PubMed
    1. Bidros D. S., Vogelbaum M. A. (2009). Novel drug delivery strategies in neuro-oncology. Neurotherapeutics 6, 539–546. 10.1016/j.nurt.2009.04.004 - DOI - PMC - PubMed
    1. Braun S., Oppermann H., Mueller A., Renner C., Hovhannisyan A., Baran-Schmidt R., et al. . (2012). Hedgehog signaling in glioblastoma multiforme. Cancer Biol. Ther. 13, 487–495. 10.4161/cbt.19591 - DOI - PubMed
    1. Chertok B., Moffat B. A., David A. E., Yu F., Bergemann C., Ross B. D., et al. . (2008). Iron oxide nanoparticles as a drug delivery vehicle for MRI monitored magnetic targeting of brain tumors. Biomaterials 29, 487–496. 10.1016/j.biomaterials.2007.08.050 - DOI - PMC - PubMed

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