Spatially gradated hydrogel platform as a 3D engineered tumor microenvironment

Abstract

There is an acute need for biomaterial tools that recreate the heterogeneous brain-tumor microenvironment. A microfluidic mixing tool is reported to encapsulate glioblastoma multiforme cells within miniaturized gelatin hydrogels containing overlapping patterns of tumor-inspired matrix signals. This approach permits in situ analysis of glioma cells at the molecular and genomic level as well as the potential for clinical insight.

Keywords: glioblastoma; gradient; hydrogel; microfluidics; tumor microenvironment.