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Comment
. 2014 Dec 17;84(6):1105-7.
doi: 10.1016/j.neuron.2014.12.012.

Please mind the gap: axonal transport deficits in multiple sclerosis neurodegeneration

Calliope A Dendrou  1 , Lars Fugger  2
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Free article
Comment

Please mind the gap: axonal transport deficits in multiple sclerosis neurodegeneration

Calliope A Dendrou et al. Neuron. .
Free article

Abstract

In this issue, Sorbara et al. (2014) demonstrate that axonal transport impairment is an early feature of neurodegeneration in multiple sclerosis models. This transport deficit is reversible by anti-inflammatory intervention but, if untreated, can contribute to late-stage axonal dystrophy.

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  • Pervasive axonal transport deficits in multiple sclerosis models.
    Sorbara CD, Wagner NE, Ladwig A, Nikić I, Merkler D, Kleele T, Marinković P, Naumann R, Godinho L, Bareyre FM, Bishop D, Misgeld T, Kerschensteiner M. Sorbara CD, et al. Neuron. 2014 Dec 17;84(6):1183-90. doi: 10.1016/j.neuron.2014.11.006. Epub 2014 Nov 26. Neuron. 2014. PMID: 25433639

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