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. 2015 Jan 21;137(2):624-7.
doi: 10.1021/ja511913h. Epub 2015 Jan 12.

Merging photoredox and nickel catalysis: decarboxylative cross-coupling of carboxylic acids with vinyl halides

Adam Noble  1 , Stefan J McCarver, David W C MacMillan
Affiliations

Merging photoredox and nickel catalysis: decarboxylative cross-coupling of carboxylic acids with vinyl halides

Adam Noble et al. J Am Chem Soc. .

Abstract

Decarboxylative cross-coupling of alkyl carboxylic acids with vinyl halides has been accomplished through the synergistic merger of photoredox and nickel catalysis. This new methodology has been successfully applied to a variety of α-oxy and α-amino acids, as well as simple hydrocarbon-substituted acids. Diverse vinyl iodides and bromides give rise to vinylation products in high efficiency under mild, operationally simple reaction conditions.

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Figures

Scheme 1
Scheme 1. Mechanism of Decarboxylative Olefination
See this image and copyright information in PMC

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