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. 1989 Nov;63(11):4958-61.
doi: 10.1128/JVI.63.11.4958-4961.1989.

A common site for immortalizing proviral integrations in Friend erythroleukemia: molecular cloning and characterization

R Paul  1 , S Schuetze, S L Kozak, D Kabat
Affiliations

A common site for immortalizing proviral integrations in Friend erythroleukemia: molecular cloning and characterization

R Paul et al. J Virol. 1989 Nov.

Abstract

By using a tagged derivative of Friend spleen focus-forming virus, we previously obtained evidence that proviral integration(s) in the host genome can cause erythroblast immortality by abrogating the commitment of the cell to differentiate (C. Spiro, B. Gliniak, and D. Kabat, J. Virol. 62:4129-4135, 1988). Exploiting the fact that each leukemia was a single clone that contained one tagged provirus, we have now molecularly cloned and characterized one common genomic site for immortalizing proviral integrations.

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