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. 1989 Nov;63(11):4965-8.
doi: 10.1128/JVI.63.11.4965-4968.1989.

Duck hepatitis B virus can tolerate insertion, deletion, and partial frameshift mutation in the distal pre-S region

J S Li  1 , L Cova, R Buckland, V Lambert, G Deléage, C Trépo
Affiliations

Duck hepatitis B virus can tolerate insertion, deletion, and partial frameshift mutation in the distal pre-S region

J S Li et al. J Virol. 1989 Nov.

Abstract

In-frame and frameshift mutations were introduced into the pre-S region (1,212 base pairs) of duck hepatitis B virus. The in-frame mutants retained the inserted 12 nucleotides, while the frameshift mutants either reverted to wild type or exhibited a 10-nucleotide compensatory deletion downstream of the original mutation site. Thus, although duck hepatitis B virus has a compact and highly economical genome organization, it can replicate despite alterations of up to 9 amino acid codons in the pre-S and P open reading frames.

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