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. 2014 Dec 18;10(12):e1004874.
doi: 10.1371/journal.pgen.1004874. eCollection 2014 Dec.

Distinct genealogies for plasmids and chromosome

Mark Achtman  1 , Zhemin Zhou  1
Affiliations

Distinct genealogies for plasmids and chromosome

Mark Achtman et al. PLoS Genet. .
No abstract available

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Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Figure 1
Figure 1. Population structure of E. coli according to MLST and core genome sequences.
MLST provides much lower resolution than do genomic sequences, but both types of data indicate that much of the general population structure consists of clusters of related bacterial isolates that are more distantly related to those in discrete clusters. In both approaches, genetic distances are calculated on genes within the core genome and exclude genes on mobile genetic elements in the accessory genome (plasmids, bacteriophages, ICEs, transposons, and IS elements), which are readily transmitted between unrelated bacterial clusters and are also frequently lost. (A) Minimal spanning tree of allelic differences at seven MLST gene fragments for 540 bacterial isolates that are in the related ST95 (267 isolates), ST131 (193), and ST648 (80) complexes. The data is from the E. coli MLST website (http://mlst.warwick.ac.uk), and color-coding reflects pathogen type. (B) Minimal spanning tree of pairwise differences at core genome SNPs from 91 Shiga toxin-producing E. coli (STEC) (O6:H16: 2 isolates; O121:H19:26; O145:NM: 7; O157:H7/H-: 56). Color-coded by serotype. The genomic analysis was performed by Hannes Pouseele (Applied Maths, Belgium) with the permission of Rebecca Lindsey, Eija Trees, Nancy Strockbine, and Peter Gerner-Smidt (Centers for Disease Control and Prevention (CDC), Atlanta, Georgia). Minimal spanning trees were calculated with Bionumerics (Applied Maths).
See this image and copyright information in PMC

References

    1. Achtman M (2011) A broad brush, global overview of bacterial sexuality. PLoS Genet 7: e1002255. - PMC - PubMed
    1. Lanza VF, de Toro M, Garcillan-Barcia MP, Mora A, Blanco J, et al. (2014) Plasmid flux in Escherichia coli ST131 sublineages, analyzed by plasmid constellation network (PLACNET), a new method for plasmid reconstruction from whole genome sequences. PLoS Genet 10: e1004766 - PMC - PubMed
    1. de Been M, Lanza VF, de Toro M, Scharringa J, Dohmen W, et al. (2014) Dissemination of cephalosporing resistance genes between Escherichia coli strains from farm animals and humans by specific plasmid lineages. PLoS Genet 10: e1004776 - PMC - PubMed
    1. Demay C, Liens B, Burguiere T, Hill V, Couvin D, et al. (2012) SITVITWEB—a publicly available international multimarker database for studying Mycobacterium tuberculosis genetic diversity and molecular epidemiology. Infect Genet Evol 12: 755–766. - PubMed
    1. Nasser W, Beres SB, Olsen RJ, Dean MA, Rice KA, et al. (2014) Evolutionary pathway to increased virulence and epidemic group A Streptococcus disease derived from 3,615 genome sequences. Proc Natl Acad Sci U S A 111: E1768–E1776. - PMC - PubMed

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