Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2015 Jan;37(1):e19-22.
doi: 10.1097/MPH.0000000000000175.

Secondary antifungal prophylaxis in pediatric hematopoietic stem cell transplants

Fatih M Azik  1 , Hasan Tezer, Aslinur Ozkaya-Parlakay, Tekin Aksu, Cengiz Bayram, Ali Fettah, Betül Tavil, Bahattin Tunç
Affiliations

Secondary antifungal prophylaxis in pediatric hematopoietic stem cell transplants

Fatih M Azik et al. J Pediatr Hematol Oncol. 2015 Jan.

Abstract

Invasive fungal infections (IFIs) constitute a leading cause of morbidity and infection-related mortality among hematopoietic stem cell transplant (HSCT) recipients. With the use of secondary prophylaxis, a history of IFI is not an absolute contraindication to allo-HSCT. However, still, IFI recurrence remains a risk factor for transplant-related mortality. In this study, of the 105 children undergoing HSCT between April 2010 and February 2013, 10 patients who had IFI history before transplantation and had undergone allo-HSCT were evaluated retrospectively to investigate results of secondary prophylaxis. In conclusion, our study shows that amphotericin B and caspofungin was successful as secondary antifungal prophylaxis agents with no relapse of IFI. In addition, after engraftment, secondary prophylaxis was continued with voriconazole orally in 4 patients that yielded good results.

PubMed Disclaimer