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. 2015 Apr;17(4):304-10.
doi: 10.1016/j.micinf.2014.12.001. Epub 2014 Dec 15.

The fungal microbiota of de-novo paediatric inflammatory bowel disease

I Mukhopadhya  1 , R Hansen  2 , C Meharg  3 , J M Thomson  1 , R K Russell  4 , S H Berry  1 , E M El-Omar  1 , G L Hold  5
Affiliations

The fungal microbiota of de-novo paediatric inflammatory bowel disease

I Mukhopadhya et al. Microbes Infect. 2015 Apr.

Abstract

Inflammatory bowel disease (IBD) is characterised by an inappropriate chronic immune response against resident gut microbes. This may be on account of distinct changes in the gut microbiota termed as dysbiosis. The role of fungi in this altered luminal environment has been scarcely reported. We studied the fungal microbiome in de-novo paediatric IBD patients utilising next generation sequencing and compared with adult disease and normal controls. We report a distinct difference in fungal species with Ascomycota predominating in control subjects compared to Basidiomycota dominance in children with IBD, which could be as a result of altered tolerance in these patients.

Keywords: Fungal microbiota; Gut microbiota; Paediatric inflammatory bowel disease.

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Figures

Fig. 1
Fig. 1
Individual patient phylum-level diversity assessment as stacked bars.
Fig. 2
Fig. 2
Individual patient genus-level diversity assessment as stacked bars.
See this image and copyright information in PMC

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