Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2015 Mar-Apr;19(2):118-24.
doi: 10.1016/j.bjid.2014.10.003. Epub 2014 Dec 15.

Clinical relevance of rhinovirus infections among adult hospitalized patients

Alberto Fica  1 , Jeannette Dabanch  2 , Winston Andrade  3 , Patricia Bustos  2 , Ita Carvajal  4 , Carolina Ceroni  4 , Vjera Triantafilo  4 , Marcelo Castro  5 , Rodrigo Fasce  3
Affiliations

Clinical relevance of rhinovirus infections among adult hospitalized patients

Alberto Fica et al. Braz J Infect Dis. 2015 Mar-Apr.

Abstract

Human rhinovirus (HRV) is an emerging viral pathogen.

Aim: To characterize a group of patients admitted due to infection by this agent in a general hospital in Chile.

Methods: Cases were identified by RT-PCR for 1 year through active surveillance of patients admitted with severe respiratory illness. Diagnosis was not available during hospitalization. Thirty-two cases were identified, 90% were ≥60 years old or had co-morbid conditions. Human rhinovirus-related admissions represented 23.7% of hospitalization due to severe acute respiratory infections among adults and ranked second to influenza (37.8%). Patients presented with pneumonia (68.8%), decompensated chronic lung conditions (21.9%), heart failure or influenza-like illness (6.3% each). Admission to intensive or intermediate care units was required by 31.2% and in-hospital mortality reached 12.5%. A CURB-65 score ≥3 was significantly associated to in-hospital mortality (p<0.05). Most patients received antibiotics (90%).

Conclusions: Human rhinovirus infections in elderly patients with co-morbid conditions are associated with hospitalizations, requiring critical or semi-critical antibiotics use. A high CURB-65 score was associated to in-hospital mortality.

Keywords: Adult; Hospitalization; Respiratory tract infections; Reverse transcriptase polymerase chain reaction; Rhinovirus; Viral pneumonia.

PubMed Disclaimer

Figures

Fig. 1
Fig. 1
Monthly distribution of 32 patients admitted with human rhinovirus-associated severe acute respiratory infection during one year at a general hospital in Chile.
Fig. 2
Fig. 2
(A) ROC analysis for CURB-65 and CAP-PIRO score to predict in-hospital mortality. All patients were included. (B) ROC analysis for the subgroup with pneumonia.
See this image and copyright information in PMC

References

    1. Graat J.M., Schouten E.G., Heijnen M.L.A., et al. A prospective, community-based study on virologic assessment among elderly people with and without symptoms of acute respiratory infection. J Clin Epidemiol. 2003;56:1218–1223. - PMC - PubMed
    1. Van Gageldonk-Lafeber A.B., Heijnen M.L.A., Bartelds A.I.M., Peters M.F., van der Plas M.S., Wilbrink B. A case-control study of acute respiratory tract infection in general practice patients in the Netherlands. Clin Infect Dis. 2005;41:490–497. - PMC - PubMed
    1. Jennings L.C., Anderson T.P., Beynon K.A., et al. Incidence and characteristics of viral community-acquired pneumonia in adults. Thorax. 2008;63:42–48. - PubMed
    1. Asner S., Peci A., Marchand-Austin A., et al. Respiratory viral infection in institutions from late stage of the first and second waves of pandemic influenza A (H1N1) 2009, Ontario, Canada. Influenza Other Respi Viruses. 2012;6:e11–e15. - PMC - PubMed
    1. Armstrong M., Fica A., Dabanch J., Olivares F., Fasce R., Triantafilo V. Morbidity and mortality associated to influenza A (H1N1) 2009 admissions in two hospitals of the Metropolitan area and analysis of its economic impact. Rev Chilena Infectol. 2012;29:664–671. - PubMed

MeSH terms

LinkOut - more resources