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. 1989 Oct 12;341(6242):503-7.
doi: 10.1038/341503a0.

Phosphorylation of large tumour antigen by cdc2 stimulates SV40 DNA replication

D McVey  1 , L Brizuela, I Mohr, D R Marshak, Y Gluzman, D Beach
Affiliations

Phosphorylation of large tumour antigen by cdc2 stimulates SV40 DNA replication

D McVey et al. Nature. .

Abstract

Simian virus 40 large tumour antigen (T) is a replication origin binding protein required for viral DNA synthesis. Unphosphorylated T antigen is deficient in promoting DNA replication in vitro but can be activated by phosphorylation at residue threonine 124 by the cdc2 protein kinase. This observation demonstrates that T is regulated by phosphorylation and provides a model for cdc2 function in the control of DNA replication.

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