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. 1989 Sep 25;17(18):7315-24.
doi: 10.1093/nar/17.18.7315.

Transcriptional trans-repression by the c-myb proto-oncogene product

H Nakagoshi  1 , T Nagase, Y Ueno, S Ishii
Affiliations
Free PMC article

Transcriptional trans-repression by the c-myb proto-oncogene product

H Nakagoshi et al. Nucleic Acids Res. .
Free PMC article

Abstract

We report that the c-myb protein binds to another site, MBS-II, in the SV40 enhancer with low affinity. In co-transfection experiments with a c-myb expression plasmid, tandem repeats of the sequence containing the MBS-II site induced c-myb-dependent transcriptional repression. Results of mutational analyses of the sequence around the MBS-II site suggested that the c-myb protein represses transcription by competing with another trans-activator. These results indicate that c-myb protein can regulate transcription not only positively but also negatively.

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References

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