Elevated HbA1c is associated with increased risk of incident dementia in primary care patients

Alfredo Ramirez¹, Steffen Wolfsgruber², Carolin Lange³, Hanna Kaduszkiewicz³, Siegfried Weyerer⁴, Jochen Werle⁴, Michael Pentzek⁵, Angela Fuchs⁵, Steffi G Riedel-Heller⁶, Tobias Luck⁷, Edelgard Mösch⁸, Horst Bickel⁸, Birgitt Wiese⁹, Jana Prokein⁹, Hans-Helmut König¹⁰, Christian Brettschneider¹⁰, Monique M Breteler¹¹, Wolfgang Maier², Frank Jessen², Martin Scherer³; AgeCoDe Study Group

Collaborators, Affiliations

Collaborators

AgeCoDe Study Group:
Heinz-Harald Abholz, Cadja Bachmann, Hendrik van den Bussche, Sandra Eifflaender-Gorfer, Marion Eisele, Annette Ernst, Kathrin Heser, Teresa Kaufeler, Mirjam Köhler, Alexander Koppara, Melanie Luppa, Manfred Mayer, Anna Schumacher, Janine Stein, Franziska Tebarth, Michael Wagner, Klaus Weckbecker, Dagmar Weeg, Thomas Zimmermann

Affiliations

¹ Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany Institute of Human Genetic, University of Bonn, Bonn, Germany.
² Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany German Center for Neurodegenerative Disorders (DZNE, Bonn), Bonn, Germany.
³ Department of Primary Medical Care, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany.
⁴ Central Institute of Mental Health, Medical Faculty Mannheim/Heidelberg University, Mannheim, Germany.
⁵ Institute of General Practice, Medical Faculty of the Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany.
⁶ Institute of Social Medicine, Occupational Health and Public Health, University of Leipzig, Leipzig, Germany.
⁷ Institute of Social Medicine, Occupational Health and Public Health, University of Leipzig, Leipzig, Germany LIFE - Leipzig Research Center for Civilization Diseases, University of Leipzig, Leipzig, Germany.
⁸ Department of Psychiatry, Technische Universität München, Klinikum rechts der Isar, Munich, Germany.
⁹ Institute of Biometrics, Hannover Medical School, Hannover, Germany.
¹⁰ Department of Medical Sociology and Health Economics, Hamburg Center for Health Economics, University Medical Center Hamburg, Hamburg, Germany.
¹¹ German Center for Neurodegenerative Disorders (DZNE, Bonn), Bonn, Germany.

PMID: 25524954
DOI: 10.3233/JAD-141521

Elevated HbA1c is associated with increased risk of incident dementia in primary care patients

Alfredo Ramirez et al. J Alzheimers Dis. 2015.

. 2015;44(4):1203-12.

doi: 10.3233/JAD-141521.

Authors

Collaborators

AgeCoDe Study Group:
Heinz-Harald Abholz, Cadja Bachmann, Hendrik van den Bussche, Sandra Eifflaender-Gorfer, Marion Eisele, Annette Ernst, Kathrin Heser, Teresa Kaufeler, Mirjam Köhler, Alexander Koppara, Melanie Luppa, Manfred Mayer, Anna Schumacher, Janine Stein, Franziska Tebarth, Michael Wagner, Klaus Weckbecker, Dagmar Weeg, Thomas Zimmermann

Affiliations

¹ Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany Institute of Human Genetic, University of Bonn, Bonn, Germany.
² Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany German Center for Neurodegenerative Disorders (DZNE, Bonn), Bonn, Germany.
³ Department of Primary Medical Care, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany.
⁴ Central Institute of Mental Health, Medical Faculty Mannheim/Heidelberg University, Mannheim, Germany.
⁵ Institute of General Practice, Medical Faculty of the Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany.
⁶ Institute of Social Medicine, Occupational Health and Public Health, University of Leipzig, Leipzig, Germany.
⁷ Institute of Social Medicine, Occupational Health and Public Health, University of Leipzig, Leipzig, Germany LIFE - Leipzig Research Center for Civilization Diseases, University of Leipzig, Leipzig, Germany.
⁸ Department of Psychiatry, Technische Universität München, Klinikum rechts der Isar, Munich, Germany.
⁹ Institute of Biometrics, Hannover Medical School, Hannover, Germany.
¹⁰ Department of Medical Sociology and Health Economics, Hamburg Center for Health Economics, University Medical Center Hamburg, Hamburg, Germany.
¹¹ German Center for Neurodegenerative Disorders (DZNE, Bonn), Bonn, Germany.

PMID: 25524954
DOI: 10.3233/JAD-141521

Abstract

Type 2 diabetes mellitus (T2DM) is a risk factor of dementia. The effect of T2DM treatment quality on dementia risk, however, is unclear. 1,342 elderly individuals recruited via general practitioner registries (AgeCoDe cohort) were analyzed. This study analyzed the association between HbA1c level and the incidence of all-cause dementia (ACD) and of Alzheimer's disease dementia (referred to here as AD). HbA1c levels ≥6.5% were associated with 2.8-fold increased risk of incident ACD (p = 0.027) and for AD (p = 0.047). HbA1c levels ≥7% were associated with a five-fold increased risk of incident ACD (p = 0.001) and 4.7-fold increased risk of incident AD (p = 0.004). The T2DM diagnosis per se did not increase the risk of either ACD or AD. Higher levels of HbA1c are associated with increased risk of ACD and AD in an elderly population. T2DM diagnosis was not associated with increased risk if HbA1c levels were below 7%.

Keywords: Alzheimer's disease; diabetes mellitus; epidemiology; glycosylated hemoglobin; incident dementia.

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Elevated HbA1c is associated with increased risk of incident dementia in primary care patients

Collaborators

Affiliations

Elevated HbA1c is associated with increased risk of incident dementia in primary care patients

Authors

Collaborators

Affiliations

Abstract

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LinkOut - more resources

Full Text Sources

Medical