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. 2015 Apr;70(4):1146-9.
doi: 10.1093/jac/dku499. Epub 2014 Dec 18.

Transmitted HIV drug resistance at the Thai Red Cross anonymous clinic in Bangkok: results from three consecutive years of annual surveillance

Sunee Sirivichayakul  1 , Rami Kantor  2 , Allison K DeLong  2 , Rapeeporn Wongkunya  3 , Suwanna Mekprasan  1 , Kiat Ruxrungtham  4 , Annette H Sohn  5 , Praphan Phanuphak  6
Affiliations

Transmitted HIV drug resistance at the Thai Red Cross anonymous clinic in Bangkok: results from three consecutive years of annual surveillance

Sunee Sirivichayakul et al. J Antimicrob Chemother. 2015 Apr.

Abstract

Objectives: The aim of this study was to prospectively survey transmitted drug resistance (TDR) among recently infected individuals (mostly MSM).

Methods: TDR was determined in prospective annual cohorts of recently HIV-1-infected individuals consecutively recruited from 2008 to 2010. Resistance interpretation was carried out using Stanford Database tools and the WHO surveillance drug resistance mutation list. Kruskal-Wallis and Fisher's exact tests were used to compare demographic and laboratory outcomes.

Results: A total of 299 subjects were enrolled, with 89% MSM. Median viral load was significantly higher in 2010 than in 2008 (P=0.004). Of the 284 analysable reverse transcriptase/protease sequences, TDR to any drug was found in 14/284 (4.9%); 4.0% in 2008, 5.9% in 2009 and 5.3% in 2010, with an increasing trend of TDR to NRTIs and NNRTIs from 2008 to 2010 (P=0.07). Good correlation was found between our data and the WHO threshold surveillance method. Only rilpivirine had significantly higher (P<0.05) predicted resistance in 2010 than in 2008 and 2009.

Conclusions: A trend towards an increase in TDR in Thailand where the major epidemic is among MSM was observed, but did not reach the WHO-defined high-level threshold (>15%). Attention to prevent the development and spread of drug resistance is needed.

Keywords: Thailand; recent infection; surveillance drug resistance mutation; transmitted drug resistance.

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References

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