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Review
. 2014 Nov 25:8:1629-34.
doi: 10.2147/PPA.S38830. eCollection 2014.

Alitretinoin for the treatment of severe chronic hand eczema

Thomas King  1 , John McKenna  1 , Anton B Alexandroff  1
Affiliations
Review

Alitretinoin for the treatment of severe chronic hand eczema

Thomas King et al. Patient Prefer Adherence. .

Abstract

Chronic hand eczema is a common and often debilitating condition. Alitretinoin, a 9-cis-retinoic acid and pan-retinoic acid agonist, is a new and effective systemic treatment for chronic hand eczema, which provides another treatment option. A "clear" or "almost clear" response can be achieved in up to half of patients within a 24-week course of treatment. Even higher rates of remission can be obtained with a longer duration of treatment. Alitretinoin has a favorable overall profile of adverse effects; however, female patients who are at risk of becoming pregnant should follow a strict pregnancy-prevention program due to the teratogenic effects of this drug.

Keywords: CTCL; dermatitis; toctino.

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References

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