Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Randomized Controlled Trial
. 2014:2014:245907.
doi: 10.1155/2014/245907. Epub 2014 Nov 30.

Effects of continuous use of Entonox in comparison with intermittent method on obstetric outcomes: a randomized clinical trial

Jila Agah  1 , Roya Baghani  2 , Seid Hossein Safiabadi Tali  3 , Yaser Tabarraei  4
Affiliations
Randomized Controlled Trial

Effects of continuous use of Entonox in comparison with intermittent method on obstetric outcomes: a randomized clinical trial

Jila Agah et al. J Pregnancy. 2014.

Abstract

Background: Entonox (N2O2) which is an inhalational gas for relieving labor pain is commonly used intermittently; however some women are interested in continuous breathing in face mask. So we decided to compare the complications induced by two methods to find out whether it is safe to permit the mothers to use Entonox continuously or not.

Patients and methods: This randomized clinical trial was performed in Mobini Hospital, Sabzevar, Iran. 50 parturients used Entonox intermittently and 50 cases used it continuously during labor. Then obstetrical outcomes were analyzed in two groups by spss 17 software, t-test, and Chi(2) while P < 0.05 was considered significant.

Results: This study showed the mean duration of second stage of labor had no significant difference (P = 0.3). Perineal laceration was less in continuous group significantly (P = 0.04). Assisted vaginal birth was not different significantly (P = 0.4). Uterine atony had no significant difference in two groups (P = 0.2). Maternal collaboration in pushing and satisfaction were higher in continuous group significantly (P = 0.03), (P < 0.0001). Apgar score of neonates at first and fifth minute was acceptable and not different significantly in two groups (P = 0.3).

Conclusions: Our study demonstrated continuous method is also safe. So, it seems reasonable to set mothers free to choose the desired method of Entonox usage.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Comparison of perineal laceration rate in continuous versus intermittent method of Entonox.
Figure 2
Figure 2
Comparison of Apgar in the first and fifth minutes between two groups.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Cunningham F. G., Leveno J. K., Bloom L. S., Hauth C. J., Rouse J. D., Spong Y. C. Williams Obstetrics. 23th. New York, NY, USA: McGraw-Hill; 2010.
    1. Collins M. R., Starr S. A., Bishop J. T., Baysinger C. L. Nitrous oxide for labor analgesia: expanding analgesic options for women in the United States. Reviews in Obstetrics & Gynecology. 2012;5(3-4):e126–e131. - PMC - PubMed
    1. Pain relief in childbirth. http://www.entonox.co.uk/en/entonox in medical_therapy with entonox/obst....
    1. Likis F. E., Andrews J. A., Collins M. R., Lewis R. M., Seroogy J. J., Starr S. A., Walden R. R., McPheeters M. L. Comparative Effectiveness Review. 67, AHRQ Publication no. 12-EHC071-EF. Rockville, Md, USA: Agency for Healthcare Research and Quality; Nitrous oxide for the management of labor pain. http://www.effectivehealthcare.ahrq.gov/reports/final.cfm. - PubMed
    1. King T. L., Wong C. A. Nitrous oxide for labor pain: is it a laughing matter? Anesthesia and Analgesia. 2014;118(1):12–14. doi: 10.1213/ANE.0000000000000017. - DOI - PubMed

Publication types

LinkOut - more resources