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. 2014 Apr 12;3(1):1-8.
doi: 10.5528/wjtm.v3.i1.1.

Epithelial ovarian cancer: An overview

Arpita Desai  1 , Jingyao Xu  2 , Kartik Aysola  2 , Yunlong Qin  2 , Chika Okoli  2 , Ravipati Hariprasad  3 , Ugorji Chinemerem  3 , Candace Gates  2 , Avinash Reddy  2 , Omar Danner  4 , Geary Franklin  2 , Anachebe Ngozi  2 , Guilherme Cantuaria  5 , Karan Singh  6 , William Grizzle  6 , Charles Landen  6 , Edward E Partridge  6 , Valerie Montgomery Rice  2 , E Shyam P Reddy  2 , Veena N Rao  2
Affiliations

Epithelial ovarian cancer: An overview

Arpita Desai et al. World J Transl Med. .

Abstract

Ovarian cancer is the second most common gynecological cancer and the leading cause of death in the United States. In this article we review the diagnosis and current management of epithelial ovarian cancer which accounts for over 95 percent of the ovarian malignancies. We will present various theories about the potential origin of ovarian malignancies. We will discuss the genetic anomalies and syndromes that may cause ovarian cancers with emphasis on Breast cancer type 1/2 mutations. The pathology and pathogenesis of ovarian carcinoma will also be presented. Lastly, we provide a comprehensive overview of treatment strategies and staging of ovarian cancer, conclusions and future directions.

Keywords: Breast cancer type 1; Chemotherapy; Epithelial ovarian cancer.

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