Comment
doi: 10.1016/j.immuni.2014.12.009.
Treg cells and CTLA-4: the ball and chain of the germinal center response
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- PMID: 25526300
- DOI: 10.1016/j.immuni.2014.12.009
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Comment
Treg cells and CTLA-4: the ball and chain of the germinal center response
Immunity.
.
Free article
Abstract
The mechanism by which regulatory T cells control the germinal center response is unknown. In this issue of Immunity, Wing et al. (2014) and Sage et al. (2014) demonstrate that CTLA-4 is a critical effector molecule used by regulatory T cells to control the germinal center.
Copyright © 2014 Elsevier Inc. All rights reserved.
Comment on
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Regulatory T cells control antigen-specific expansion of Tfh cell number and humoral immune responses via the coreceptor CTLA-4.Immunity. 2014 Dec 18;41(6):1013-25. doi: 10.1016/j.immuni.2014.12.006. Epub 2014 Dec 6. Immunity. 2014. PMID: 25526312
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The coinhibitory receptor CTLA-4 controls B cell responses by modulating T follicular helper, T follicular regulatory, and T regulatory cells.Immunity. 2014 Dec 18;41(6):1026-39. doi: 10.1016/j.immuni.2014.12.005. Epub 2014 Dec 5. Immunity. 2014. PMID: 25526313 Free PMC article.
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