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Comment
. 2014 Dec 18;41(6):883-5.
doi: 10.1016/j.immuni.2014.12.014.

Take your PICS: moving from GWAS to immune function

Stephen Eyre  1 , Jane Worthington  2
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Free article
Comment

Take your PICS: moving from GWAS to immune function

Stephen Eyre et al. Immunity. .
Free article

Abstract

Many of the hits identified through genome-wide association studies are located outside protein-coding regions, making it difficult to define mechanism. In Nature, Farh et al., (2014) describe an approach to identify causal variants in autoimmune disease as first step to assigning function.

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  • Genetic and epigenetic fine mapping of causal autoimmune disease variants.
    Farh KK, Marson A, Zhu J, Kleinewietfeld M, Housley WJ, Beik S, Shoresh N, Whitton H, Ryan RJ, Shishkin AA, Hatan M, Carrasco-Alfonso MJ, Mayer D, Luckey CJ, Patsopoulos NA, De Jager PL, Kuchroo VK, Epstein CB, Daly MJ, Hafler DA, Bernstein BE. Farh KK, et al. Nature. 2015 Feb 19;518(7539):337-43. doi: 10.1038/nature13835. Epub 2014 Oct 29. Nature. 2015. PMID: 25363779 Free PMC article.

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