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. 2015 Mar;100(3):e102-5.
doi: 10.3324/haematol.2014.119248. Epub 2014 Dec 19.

Hedgehog pathway mutations in T-cell acute lymphoblastic leukemia

Antonis Dagklis  1 , Daphnie Pauwels  1 , Idoya Lahortiga  1 , Ellen Geerdens  1 , Emilie Bittoun  2 , Barbara Cauwelier  3 , Thomas Tousseyn  2 , Anne Uyttebroeck  4 , Johan Maertens  5 , Gregor Verhoef  5 , Peter Vandenberghe  6 , Jan Cools  7
Affiliations

Hedgehog pathway mutations in T-cell acute lymphoblastic leukemia

Antonis Dagklis et al. Haematologica. 2015 Mar.
No abstract available

Keywords: Hedgehog pathway; leukemia; oncogene; signaling.

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Figures

Figure 1.
Figure 1.
Sanger sequencing profiles of T-ALL cases with Hedgehog pathway mutations. Sanger sequencing in 6 TALL cases on DNA from diagnosis and germline DNA confirmed that 4 of the 6 Hedgehog pathway mutations were somatic mutations.
Figure 2.
Figure 2.
Identification of acquired mutations in the Hedgehog pathway. (A) Functional analysis of the SMO-R763* mutant was performed in HEK293T cells. The proliferation of the cells was measured 4, 5 and 6 days after transfection (cell numbers at day 4 are shown). The experiment was repeated three times and each sample was analyzed in triplicate. The total amount of DNA used for the transfections was constant. WT: wild type. (B) Frequency of CD4CD8 double negative (DN) population in the thymus of Balb/C mice transplanted with hematopoietic progenitor cells expressing various SMO mutants.
See this image and copyright information in PMC

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