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Multicenter Study
. 2015 Apr;21(4):640-5.
doi: 10.1016/j.bbmt.2014.10.022. Epub 2014 Dec 18.

Center for International Blood and Marrow Transplant Research chronic graft-versus-host disease risk score predicts mortality in an independent validation cohort

Mukta Arora  1 , Michael T Hemmer  2 , Kwang Woo Ahn  3 , John P Klein  3 , Corey S Cutler  4 , Alvaro Urbano-Ispizua  5 , Daniel R Couriel  6 , Amin M Alousi  7 , Robert Peter Gale  8 , Yoshihiro Inamoto  9 , Daniel J Weisdorf  1 , Peigang Li  2 , Joseph H Antin  4 , Brian J Bolwell  10 , Michael Boyiadzis  11 , Jean-Yves Cahn  12 , Mitchell S Cairo  13 , Luis M Isola  14 , David A Jacobsohn  15 , Madan Jagasia  16 , Thomas R Klumpp  17 , Effie W Petersdorf  18 , Stella Santarone  19 , Harry C Schouten  20 , John R Wingard  21 , Stephen R Spellman  22 , Steven Z Pavletic  23 , Stephanie J Lee  18 , Mary M Horowitz  2 , Mary E D Flowers  24
Affiliations
Multicenter Study

Center for International Blood and Marrow Transplant Research chronic graft-versus-host disease risk score predicts mortality in an independent validation cohort

Mukta Arora et al. Biol Blood Marrow Transplant. 2015 Apr.

Abstract

We previously reported a risk score that predicted mortality in patients with chronic graft-versus-host disease (CGVHD) after hematopoietic stem cell transplantation (HCT) between 1995 and 2004 and reported to the Center for International Blood and Marrow Transplant Research (CIBMTR). We sought to validate this risk score in an independent CIBMTR cohort of 1128 patients with CGVHD who underwent transplantation between 2005 and 2007 using the same inclusion criteria and risk score calculations. According to the sum of the overall risk score (range, 1 to 12), patients were assigned to 4 risk groups (RGs): RG1 (0 to 2), RG2 (3 to 6), RG3 (7 to 8), and RG4 (9 to 10). RG3 and RG4 were combined, as RG4 accounted for only 1% of the total cohort. Cumulative incidences of nonrelapse mortality (NRM) and probability of overall survival were significantly different between each RG (all P < .01). NRM and overall survival at 5 years after CGVHD for each RG were 17% and 72% in RG1, 26% and 53% in RG2, and 44% and 25% in RG3, respectively (all P < .01). Our study validates the prognostic value of the CIBMTR CGVHD RGs for overall survival and NRM in a contemporary transplantation population. The CIBMTR CGVHD RGs can be used to predict major outcomes, tailor treatment planning, and enroll patients in clinical trials.

Keywords: Chronic graft-versus-host disease (CGVHD); Nonrelapse mortality; Risk score.

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Figures

Figure 1
Figure 1
Overall Survival (A) and Non-relapse mortality (B) among patients with CGVHD according to risk score: All estimates are estimated from the date of onset of CGVHD
See this image and copyright information in PMC

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