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Review
. 2015 Jan;48(1):116-9.
doi: 10.1016/j.amepre.2014.09.031.

Lifecourse epidemiology and molecular pathological epidemiology

Akihiro Nishi  1 , Ichiro Kawachi  2 , Karestan C Koenen  3 , Kana Wu  4 , Reiko Nishihara  5 , Shuji Ogino  6
Affiliations
Review

Lifecourse epidemiology and molecular pathological epidemiology

Akihiro Nishi et al. Am J Prev Med. 2015 Jan.
No abstract available

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Conflict of interest statement

Conflict of interest: We declare that we have no conflict of interest.

Figures

Figure 1
Figure 1. Three models of lifecourse epidemiology (A) and the integrated model of molecular pathological epidemiology (MPE) and lifecourse epidemiology (B)
In section B, the ongoing molecular pathological change under the skin (orange area) can be traced from the perspective of MPE. Although addressing X1/X2 ( e.g. low socioeconomic position) can be a fundamental solution to prevent the development of Y ( e.g. cancer), X1/X2 happened in the past or are not modifiable in many situations. Therefore, the ongoing molecular pathological change at the present moment ( M; e.g. precancerous phase of adenoma) needs to be a target for behavioral interventions or preventive medical treatments to intervene the further disease development ( Y). Y reflects heterogeneity of disease process. In the other case where the vertical line of “ present” is located between X1 and X2 ( not shown), X2 can be the other targeting modifiable factor in addition to M.
See this image and copyright information in PMC

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