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Review
. 2015 Jan;114(1):6-11.
doi: 10.1016/j.anai.2014.08.016.

Child with atopic dermatitis

Watcharoot Kanchongkittiphon  1 , Jonathan M Gaffin  2 , Wanda Phipatanakul  3
Affiliations
Review

Child with atopic dermatitis

Watcharoot Kanchongkittiphon et al. Ann Allergy Asthma Immunol. 2015 Jan.
No abstract available

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Figures

Figure 1
Figure 1
Defective epidermal barrier in the pathogenesis of AD. A reduction in FLG, CLDN-1, SPINK5, and other injuries lead to increase permeation of allergen and increase trans-epidermal water loss. Decreased antimicrobial peptides, like beta-defensins and cathelicidins result in bacterial colonization. Activated DCs by TSLP from keratinocytes and by antigens stimulate proliferation of Th2 cells. Th2 cells secrete inflammatory cytokines that worsen AD severity. Mast cells, basophils, and eosinophils are induced by TSLP. Th17 cells secrete IL17 and IL22 that can cause epithelial hyperplasia. FLG: filaggrin, CLDN-1: claudin 1, SPINK5: Kazal-type serine protease inhibitor, TJ: tight junction, DC: dendritic cell, TSLP: Thymic stromal lymphopoietin, Eo: eosinophil, Ba: basophil, Mast: mast cell.
See this image and copyright information in PMC

References

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