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. 1989 Aug;33(8):1395-9.
doi: 10.1128/AAC.33.8.1395.

Herpes simplex virus ribonucleotide reductase mutants are hypersensitive to acyclovir

D M Coen  1 , D J Goldstein, S K Weller
Affiliations

Herpes simplex virus ribonucleotide reductase mutants are hypersensitive to acyclovir

D M Coen et al. Antimicrob Agents Chemother. 1989 Aug.

Erratum in

  • Antimicrob Agents Chemother 1989 Oct;33(10):1827

Abstract

Two mutants defective in herpes simplex virus-encoded ribonucleotide reductase activity exhibited the novel phenotype of hypersensitivity to acyclovir, aphidicolin, and to a lesser extent, phosphonoacetic acid. These results have implications for acyclovir resistance and the development of drugs that potentiate acyclovir action by inhibition of viral ribonucleotide reductase.

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References

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