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. 2015 Mar;21(3):389-401.e1.
doi: 10.1016/j.bbmt.2014.12.001. Epub 2014 Dec 18.

National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease: I. The 2014 Diagnosis and Staging Working Group report

Madan H Jagasia  1 , Hildegard T Greinix  2 , Mukta Arora  3 , Kirsten M Williams  4 , Daniel Wolff  5 , Edward W Cowen  6 , Jeanne Palmer  7 , Daniel Weisdorf  3 , Nathaniel S Treister  8 , Guang-Shing Cheng  9 , Holly Kerr  10 , Pamela Stratton  11 , Rafael F Duarte  12 , George B McDonald  9 , Yoshihiro Inamoto  13 , Afonso Vigorito  14 , Sally Arai  15 , Manuel B Datiles  16 , David Jacobsohn  17 , Theo Heller  18 , Carrie L Kitko  19 , Sandra A Mitchell  20 , Paul J Martin  9 , Howard Shulman  9 , Roy S Wu  21 , Corey S Cutler  22 , Georgia B Vogelsang  23 , Stephanie J Lee  9 , Steven Z Pavletic  6 , Mary E D Flowers  24
Affiliations

National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease: I. The 2014 Diagnosis and Staging Working Group report

Madan H Jagasia et al. Biol Blood Marrow Transplant. 2015 Mar.

Abstract

The 2005 National Institutes of Health (NIH) Consensus Conference proposed new criteria for diagnosing and scoring the severity of chronic graft-versus-host disease (GVHD). The 2014 NIH consensus maintains the framework of the prior consensus with further refinement based on new evidence. Revisions have been made to address areas of controversy or confusion, such as the overlap chronic GVHD subcategory and the distinction between active disease and past tissue damage. Diagnostic criteria for involvement of mouth, eyes, genitalia, and lungs have been revised. Categories of chronic GVHD should be defined in ways that indicate prognosis, guide treatment, and define eligibility for clinical trials. Revisions have been made to focus attention on the causes of organ-specific abnormalities. Attribution of organ-specific abnormalities to chronic GVHD has been addressed. This paradigm shift provides greater specificity and more accurately measures the global burden of disease attributed to GVHD, and it will facilitate biomarker association studies.

Keywords: Chronic graft-versus-host disease; Diagnosis; National Institutes of Health; Staging.

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Figures

Figure 1
Figure 1
Organ Scoring of Chronic GVHD
Figure 1
Figure 1
Organ Scoring of Chronic GVHD
Figure 1
Figure 1
Organ Scoring of Chronic GVHD
See this image and copyright information in PMC

References

    1. Lee SJ, Flowers MED. Recognizing and managing chronic graft-versus-host disease. In: Gewirtz AM, Muchmore EA, Burns LJ, editors. Hematology 2008: American Society of Hematology Education Program Book. Washington, DC: American Society of Hematology; 2008. pp. 134–141. - PubMed
    1. Lee SJ, Vogelsang G, Flowers MED. Chronic graft-versus-host disease. Biol Blood Marrow Transplant. 2003;9:215–233. - PubMed
    1. Flowers MED, Vogelsang GB. Clinical manifestations and natural history. In: Vogelsang GB, Pavletic SZ, editors. Chronic Graft Versus Host Disease: Interdisciplinary Management. New York, NY: Cambridge University Press; 2009. pp. 56–69.
    1. Filipovich AH, Weisdorf D, Pavletic S, Socie G, Wingard JR, Lee SJ, et al. National Institutes of Health consensus development project on criteria for clinical trials in chronic graft-versus-host disease: I. Diagnosis and Staging Working Group report. Biol Blood Marrow Transplant. 2005;11:945–956. - PubMed
    1. Flowers MED, Inamoto Y, Carpenter PA, Lee SJ, Kiem H-P, Petersdorf EW, et al. Comparative analysis of risk factors for acute graft-versus-host disease and for chronic graft-versus-host disease according to National Institutes of Health consensus criteria. Blood. 2011;117:3214–3219. - PMC - PubMed

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