Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2015 Jan;21(1):81-5.
doi: 10.1038/nm.3773. Epub 2014 Dec 22.

High-throughput epitope discovery reveals frequent recognition of neo-antigens by CD4+ T cells in human melanoma

Carsten Linnemann  1 , Marit M van Buuren  1 , Laura Bies  1 , Els M E Verdegaal  2 , Remko Schotte  3 , Jorg J A Calis  1 , Sam Behjati  4 , Arno Velds  5 , Henk Hilkmann  6 , Dris El Atmioui  6 , Marten Visser  2 , Michael R Stratton  4 , John B A G Haanen  7 , Hergen Spits  3 , Sjoerd H van der Burg  2 , Ton N M Schumacher  1
Affiliations

High-throughput epitope discovery reveals frequent recognition of neo-antigens by CD4+ T cells in human melanoma

Carsten Linnemann et al. Nat Med. 2015 Jan.

Erratum in

Abstract

Tumor-specific neo-antigens that arise as a consequence of mutations are thought to be important for the therapeutic efficacy of cancer immunotherapies. Accumulating evidence suggests that neo-antigens may be commonly recognized by intratumoral CD8+ T cells, but it is unclear whether neo-antigen-specific CD4+ T cells also frequently reside within human tumors. In view of the accepted role of tumor-specific CD4+ T-cell responses in tumor control, we addressed whether neo-antigen-specific CD4+ T-cell reactivity is a common property in human melanoma.

PubMed Disclaimer

References

    1. Science. 1999 May 21;284(5418):1351-4 - PubMed
    1. J Exp Med. 2010 Mar 15;207(3):637-50 - PubMed
    1. Clin Cancer Res. 2014 Jul 1;20(13):3401-10 - PubMed
    1. J Immunother. 2012 Jun;35(5):400-8 - PubMed
    1. Oncoimmunology. 2014 Jan 1;3(1):e27817 - PubMed

Publication types