High-throughput epitope discovery reveals frequent recognition of neo-antigens by CD4+ T cells in human melanoma
- PMID: 25531942
- DOI: 10.1038/nm.3773
High-throughput epitope discovery reveals frequent recognition of neo-antigens by CD4+ T cells in human melanoma
Erratum in
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Corrigendum: High-throughput epitope discovery reveals frequent recognition of neo-antigens by CD4+ T cells in human melanoma.Nat Med. 2016 Oct 6;22(10):1192. doi: 10.1038/nm1016-1192d. Nat Med. 2016. PMID: 27711057 No abstract available.
Abstract
Tumor-specific neo-antigens that arise as a consequence of mutations are thought to be important for the therapeutic efficacy of cancer immunotherapies. Accumulating evidence suggests that neo-antigens may be commonly recognized by intratumoral CD8+ T cells, but it is unclear whether neo-antigen-specific CD4+ T cells also frequently reside within human tumors. In view of the accepted role of tumor-specific CD4+ T-cell responses in tumor control, we addressed whether neo-antigen-specific CD4+ T-cell reactivity is a common property in human melanoma.
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