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. 2015 Jan;21(1):81-5.
doi: 10.1038/nm.3773. Epub 2014 Dec 22.

High-throughput epitope discovery reveals frequent recognition of neo-antigens by CD4+ T cells in human melanoma

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High-throughput epitope discovery reveals frequent recognition of neo-antigens by CD4+ T cells in human melanoma

Carsten Linnemann et al. Nat Med. 2015 Jan.

Erratum in

Abstract

Tumor-specific neo-antigens that arise as a consequence of mutations are thought to be important for the therapeutic efficacy of cancer immunotherapies. Accumulating evidence suggests that neo-antigens may be commonly recognized by intratumoral CD8+ T cells, but it is unclear whether neo-antigen-specific CD4+ T cells also frequently reside within human tumors. In view of the accepted role of tumor-specific CD4+ T-cell responses in tumor control, we addressed whether neo-antigen-specific CD4+ T-cell reactivity is a common property in human melanoma.

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References

    1. Science. 1999 May 21;284(5418):1351-4 - PubMed
    1. J Exp Med. 2010 Mar 15;207(3):637-50 - PubMed
    1. Clin Cancer Res. 2014 Jul 1;20(13):3401-10 - PubMed
    1. J Immunother. 2012 Jun;35(5):400-8 - PubMed
    1. Oncoimmunology. 2014 Jan 1;3(1):e27817 - PubMed

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