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Review
. 2015 Mar;114(3):397-402.
doi: 10.1016/j.ymgme.2014.11.017. Epub 2014 Dec 5.

Targeting novel signaling pathways for resistant acute myeloid leukemia

Kathleen M Sakamoto  1 , Steven Grant  2 , Diana Saleiro  3 , John D Crispino  3 , Nobuko Hijiya  4 , Francis Giles  3 , Leonidas Platanias  5 , Elizabeth A Eklund  5
Affiliations
Review

Targeting novel signaling pathways for resistant acute myeloid leukemia

Kathleen M Sakamoto et al. Mol Genet Metab. 2015 Mar.

Abstract

Acute myeloid leukemia (AML) is a hematologic malignancy that is the most common type of acute leukemia diagnosed in adults and the second most common type in children. The overall survival is poor and treatment is associated with significant complications and even death. In addition, a significant number of patients will not respond to therapy or relapse. In this review, several new signaling proteins aberrantly regulated in AML are described, including CREB, Triad1, Bcl-2 family members, Stat3, and mTOR/MEK. Identifying more effective and less toxic agents will provide novel approaches to treat AML.

Keywords: Acute myeloid leukemia; Novel therapies; Resistance; Signaling pathways.

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References

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