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Review
. 2015 Jan;15(1):42-54.
doi: 10.1038/nrc3858.

Modelling bladder cancer in mice: opportunities and challenges

Takashi Kobayashi  1 , Tomasz B Owczarek  2 , James M McKiernan  3 , Cory Abate-Shen  4
Affiliations
Review

Modelling bladder cancer in mice: opportunities and challenges

Takashi Kobayashi et al. Nat Rev Cancer. 2015 Jan.

Abstract

The prognosis and treatment of bladder cancer have improved little in the past 20 years. Bladder cancer remains a debilitating and often fatal disease, and is among the most costly cancers to treat. The generation of informative mouse models has the potential to improve our understanding of bladder cancer progression, as well as to affect its diagnosis and treatment. However, relatively few mouse models of bladder cancer have been described, and in particular, few that develop invasive cancer phenotypes. This Review focuses on opportunities for improving the landscape of mouse models of bladder cancer.

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Figures

Figure 1
Figure 1
A. Diagram of bladder anatomy and cell types B. Summary of expression of cytokeratins (CK), p63, and Uroplakin (Uro) in bladder urothelial cells.
Figure 2
Figure 2. Clinical stages of bladder cancer
Schematic representation of the clinical stages and grades of bladder cancer and standard treatments. TUR, transurethral resection; CIS, carcinoma in situ.
See this image and copyright information in PMC

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