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. 2015 Mar;59(3):1802-5.
doi: 10.1128/AAC.04809-14. Epub 2014 Dec 22.

Activity of eravacycline against Enterobacteriaceae and Acinetobacter baumannii, including multidrug-resistant isolates, from New York City

Marie Abdallah  1 , Olawole Olafisoye  1 , Christopher Cortes  2 , Carl Urban  2 , David Landman  1 , John Quale  3
Affiliations

Activity of eravacycline against Enterobacteriaceae and Acinetobacter baumannii, including multidrug-resistant isolates, from New York City

Marie Abdallah et al. Antimicrob Agents Chemother. 2015 Mar.

Abstract

Eravacycline demonstrated in vitro activity against a contemporary collection of more than 4,000 Gram-negative pathogens from New York City hospitals, with MIC50/MIC90 values, respectively, for Escherichia coli of 0.12/0.5 μg/ml, Klebsiella pneumoniae of 0.25/1 μg/ml, Enterobacter aerogenes of 0.25/1 μg/ml, Enterobacter cloacae 0.5/1 μg/ml, and Acinetobacter baumannii of 0.5/1 μg/ml. Activity was retained against multidrug-resistant isolates, including those expressing KPC and OXA carbapenemases. For A. baumannii, eravacycline MICs correlated with increased expression of the adeB gene.

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