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. 2015 Feb 18;27(7):1235-40.
doi: 10.1002/adma.201404448. Epub 2014 Dec 23.

A fast and activatable cross-linking strategy for hydrogel formation

Anika M Jonker  1 , Annika Borrmann, Ernst R H van Eck, Floris L van Delft, Dennis W P M Löwik, Jan C M van Hest
Affiliations

A fast and activatable cross-linking strategy for hydrogel formation

Anika M Jonker et al. Adv Mater. .

Abstract

Strain-promoted oxidation-controlled cyclo-octyne-1,2-quinone cycloaddition (SPOCQ) is a fast and activatable cross-linking strategy for hydrogel formation. Gelation is induced by oxidation, which is performed both chemically using sodium periodate and enzymatically using mushroom tyrosinase. Due to the fast reaction kinetics, SPOCQ-formed hydrogels can be functionalized in one-pot with an azido-containing moiety using SPAAC cross-linking.

Keywords: activatable; cross-linking; hydrogel; oxidation.

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