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. 2015 Feb;7(2):125-6.
doi: 10.15252/emmm.201404815.

New TB treatments hiding in plain sight

Andrew J Olive  1 , Christopher M Sassetti  2
Affiliations

New TB treatments hiding in plain sight

Andrew J Olive et al. EMBO Mol Med. 2015 Feb.

Abstract

As tuberculosis (TB) toll is revised upward according to the WHO's last estimates, the lack of vaccine strategy and the lengthy antibiotic treatments that unfortunately promote the emergence of drug resistance are a major set back in the fight against this pathogen. In this issue of EMBO Molecular Medicine, Schiebler et al (Mtb) propose a novel and compelling new approach to target Mycobacterium tuberculosis (Mtb) by pharmacologically stimulating intracellular mycobacteria clearance through autophagy.

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Figures

Figure 1
Figure 1. Metabolic modulators enhance selective autophagy
Both CBZ and MET activate AMPK by perturbing mitochondrial function. The result of these effects is an enhancement of selective autophagy, which can both kill intracellular bacteria and alter cytokine secretion from phagocytes.
See this image and copyright information in PMC

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References

    1. Bradfute SB, Castillo EF, Arko-Mensah J, Chauhan S, Jiang S, Mandell M, Deretic V. Autophagy as an immune effector against tuberculosis. Curr Opin Microbiol. 2013;16:355–365. - PMC - PubMed
    1. Casenghi M, Cole ST, Nathan CF. New approaches to filling the gap in tuberculosis drug discovery. PLoS Med. 2007;4:e293. - PMC - PubMed
    1. Castillo EF, Dekonenko A, Arko-Mensah J, Mandell MA, Dupont N, Jiang S, Delgado-Vargas M, Timmins GS, Bhattacharya D, Yang H, et al. Autophagy protects against active tuberculosis by suppressing bacterial burden and inflammation. Proc Natl Acad Sci USA. 2012;109:E3168–E3176. - PMC - PubMed
    1. Choi AM, Ryter SW, Levine B. Autophagy in human health and disease. New Engl J Med. 2013;368:651–662. - PubMed
    1. Manzanillo PS, Ayres JS, Watson RO, Collins AC, Souza G, Rae CS, Schneider DS, Nakamura K, Shiloh MU, Cox JS. The ubiquitin ligase parkin mediates resistance to intracellular pathogens. Nature. 2013;501:512–516. - PMC - PubMed

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